Synthesis 2017; 49(19): 4469-4477
DOI: 10.1055/s-0036-1589051
paper
© Georg Thieme Verlag Stuttgart · New York

An Efficient Organic Electrosynthesis of β-Hydroxysulfones

Chieh-Kai Chan
Department of Medicinal and Applied Chemistry, General Research Centers of R & D Office, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China   Email: pyc@kmu.edu.tw   Email: mychang@kmu.edu.tw
,
Nai-Chang Lo
Department of Medicinal and Applied Chemistry, General Research Centers of R & D Office, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China   Email: pyc@kmu.edu.tw   Email: mychang@kmu.edu.tw
,
Po-Yu Chen*
Department of Medicinal and Applied Chemistry, General Research Centers of R & D Office, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China   Email: pyc@kmu.edu.tw   Email: mychang@kmu.edu.tw
,
Meng-Yang Chang*
Department of Medicinal and Applied Chemistry, General Research Centers of R & D Office, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China   Email: pyc@kmu.edu.tw   Email: mychang@kmu.edu.tw
› Author Affiliations
We thank the Ministry of Science and Technology of the Republic of China for financial support (MOST 105-2113-M-037-001). This study was supported partially by Kaohsiung Medical University ‘Aim for the Top Universities Grant’ No. KMU-TP105PR02.
Further Information

Publication History

Received: 07 April 2017

Accepted after revision: 19 May 2017

Publication Date:
25 July 2017 (online)


Abstract

An efficient organic electrosynthesis of tertiary β-hydroxysulfones from functionalized α-methylstyrenes with substituted sodium sulfinates has been established. The novel electrosynthetic method provided the desired products in excellent yields, and the key structure was confirmed by X-ray single-crystal diffraction analysis.

Supporting Information