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Synlett 2017; 28(20): 2971-2975
DOI: 10.1055/s-0036-1590930
DOI: 10.1055/s-0036-1590930
letter
Enantioselective and Diastereoselective Conjugate Radical Additions to α-Arylidene Ketones and Lactones
This research was partially supported by funds from NIH RO1-54656.Further Information
Publication History
Received: 14 August 2017
Accepted after revision: 12 September 2017
Publication Date:
20 October 2017 (online)


Dedicated to Prof. Victor Snieckus on his 80th birthday
Abstract
A highly stereoselective conjugate radical addition to arylidene ketones and lactones has been developed. The conjugate radical additions using chiral salen Lewis acids proceeds with up to 99:1 dr and 87% ee in good to excellent chemical yields.
Key words
enantioselective radical reaction - arylidene ketones and lactones - diastereoselectivity - conjugate addition - chiral salen Lewis acidSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590930.
- Supporting Information