Synlett 2017; 28(20): 2971-2975
DOI: 10.1055/s-0036-1590930
letter
© Georg Thieme Verlag Stuttgart · New York

Enantioselective and Diastereoselective Conjugate Radical Additions to α-Arylidene Ketones and Lactones

Changjia Zhao
,
Mukund P. Sibi*
This research was partially supported by funds from NIH RO1-54656.
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Publication History

Received: 14 August 2017

Accepted after revision: 12 September 2017

Publication Date:
20 October 2017 (online)


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Dedicated to Prof. Victor Snieckus on his 80th birthday

Abstract

A highly stereoselective conjugate radical addition to arylidene ketones and lactones has been developed. The conjugate radical additions using chiral salen Lewis acids proceeds with up to 99:1 dr and 87% ee in good to excellent chemical yields.

Supporting Information