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Synlett 2018; 29(12): 1659-1663
DOI: 10.1055/s-0036-1591586
DOI: 10.1055/s-0036-1591586
letter
Copper-Catalyzed Cross-Dehydrogenative-Coupling Reaction of N-Arylglycine Esters with Imides or Amides for Synthesis of α-Substituted α-Amino Acid Esters
Financial supports from the National Natural Science Foundation of China (21602027, 21462001 and 11765003), the Natural Science Foundation of Jiangxi Province (20171BAB213006), the China Postdoctoral Science Foundation (2018M632595) the Foundation of Jiangxi Educational Committee (GJJ170430), and the Scientific Research Foundation of East China University of Technology (DHBK2016112) are gratefully acknowledged.Weitere Informationen
Publikationsverlauf
Received: 09. März 2018
Accepted after revision: 22. April 2018
Publikationsdatum:
05. Juni 2018 (online)


Abstract
A simple and highly efficient cross-dehydrogenative-coupling (CDC) reaction between N-aryl glycine esters and imides or amides by the catalysis of a copper salt without the requirement of peroxide agents is described. The novel reaction provides a facile approach for the synthesis of α-substituted α-amino acid esters through C–H/N–H oxidative cross-coupling. A possible mechanism for the CDC reaction by using copper as a catalyst and air as the terminal oxidant is also proposed. This synthetic approach has the advantages of good yields, simple operation and mild reaction conditions.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591586.
- Supporting Information