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Journal of Pediatric Biochemistry 2016; 06(02): 110-113
DOI: 10.1055/s-0036-1593812
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Antioxidant Effects of Lutein in Neonatal Period

Monica Tei
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
Giuseppe De Bernardo
2   Department of Emergency, UOC TIN-Neonatology, AORN Santobono-Pausilipon, Naples, Italy
,
Francesco Bazzini
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
Antonino Santacroce
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
Elisa Belvisi
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
Marina Riccitelli
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
Carlotta Bracciali
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
Giuseppe Buonocore
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
Serafina Perrone
1   Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy
,
on behalf of the “Gruppo di Studio di Biochimica Clinica Neonatale della Società Italiana di Neonatologia” › Author Affiliations
Further Information

Publication History

07 August 2016

27 August 2016

Publication Date:
25 October 2016 (online)

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Abstract

During fetal life, a right balance between oxidants and antioxidants is required for survival and growth of the fetus. At birth, an overproduction of free radicals (FRs) together with poor antioxidant defenses may be detrimental for developing organs and tissues. Protecting the newborn infant against perinatal oxidative stress (OS) is a health care priority, and therefore the search for new, safe, and efficacious antioxidants has been a major quest during the last decade. Due to its antioxidant and anti-inflammatory properties, lutein, a compound belonging to the xanthophyll family of carotenoids, is one of the most promising molecules with clinical application during neonatal age. Lutein is not synthesized by humans, hence the intake primarily depends on diet. In the neonatal period, fresh human milk is the main source of lutein, though lutein-enriched infant formulas are now available. Oral supplementation represents an alternative source of lutein, and it has been demonstrated to decrease plasma biomarkers of OS and increase antioxidant capacity in the first days of life.

Keywords

oxidative stress - free radicals - reactive oxygen species - lutein
 

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