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J Knee Surg 2018; 31(01): 099-116
DOI: 10.1055/s-0037-1602247
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Augmentation Techniques for Meniscus Repair

Leili Ghazi zadeh
1   Biomedical Engineering Institute, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada
,
Anik Chevrier
2   Department of Chemical Engineering, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada
,
Jack Farr
3   Cartilage Restoration Center, OrthoIndy, Greenwood, Indiana
,
Scott A. Rodeo
4   Department of Orthopaedics, Hospital for Special Surgery, New York, New York
,
Michael D. Buschmann
2   Department of Chemical Engineering, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada
› Author Affiliations
Further Information

Publication History

11 October 2016

09 March 2017

Publication Date:
02 May 2017 (online)

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Abstract

Menisci display exquisitely complex structure and play an essential weight-bearing role in the knee joint. A torn meniscus is one of the most common knee injuries which can result in pain and mechanical abnormalities. Tear location is one aspect which determines the endogenous healing response; tears that occur in the peripheral densely vascularized zone of the meniscus have the potential to heal while the healing capacity is more limited in the less vascularized inner zones. Meniscectomy was once widely performed, but led to poor radiographic and patient-reported mid- and long-term outcomes. After the advent of arthroscopy, orthopaedic opinion in the 1980s has been swaying toward salvaging or repairing the torn meniscus tissue to prevent osteoarthritis rather than performing meniscectomy. Meniscus repair in young active individuals has been shown to be effective, reproducible, and reliable if indications are met; however, only a small proportion of all tears are considered repairable with available technologies. Biological augmentation techniques and meniscus tissue engineering strategies are being devised to enhance the likelihood and rate of healing in meniscus repair. Preclinical and clinical studies have shown that introduction of cellular elements of the blood, bone marrow, and related growth factors have the potential to enhance meniscus repair. This article reviews the current state of clinical management of meniscus tears (primary repair) as well as augmentation techniques to improve healing by meniscus wrapping with extracellular matrix materials, trephination, synovial rasping and abrasion, fibrin/blood clot placement, and platelet-rich plasma injections. In addition, the rationale for using polymer/autologous blood component implants to improve meniscus repair will be discussed.

Keywords

meniscus repair - augmentation techniques - platelet-rich plasma - chitosan
 

  • References

  • 1 McDevitt CA, Webber RJ. The ultrastructure and biochemistry of meniscal cartilage. Clin Orthop Relat Res 1990; (252) 8-18
    PubMedSearch in Google Scholar
  • 2 Messner K, Gao J. The menisci of the knee joint. Anatomical and functional characteristics, and a rationale for clinical treatment. J Anat 1998; 193 (Pt 2): 161-178
    CrossrefPubMedSearch in Google Scholar
  • 3 Fithian DC, Kelly MA, Mow VC. Material properties and structure-function relationships in the menisci. Clin Orthop Relat Res 1990; (252) 19-31
    PubMedSearch in Google Scholar
  • 4 Englund M, Guermazi A, Gale D. , et al. Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med 2008; 359 (11) 1108-1115
    CrossrefPubMedSearch in Google Scholar
  • 5 Englund M, Guermazi A, Roemer FW. , et al. Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: the Multicenter Osteoarthritis Study. Arthritis Rheum 2009; 60 (03) 831-839
    CrossrefPubMedSearch in Google Scholar
  • 6 Zanetti M, Pfirrmann CWA, Schmid MR, Romero J, Seifert B, Hodler J. Clinical course of knees with asymptomatic meniscal abnormalities: findings at 2-year follow-up after MR imaging-based diagnosis. Radiology 2005; 237 (03) 993-997
    CrossrefPubMedSearch in Google Scholar
  • 7 Abrams GD, Frank RM, Gupta AK, Harris JD, McCormick FM, Cole BJ. Trends in meniscus repair and meniscectomy in the United States, 2005-2011. Am J Sports Med 2013; 41 (10) 2333-2339
    CrossrefPubMedSearch in Google Scholar
  • 8 Fairbanks TJ. Knee joint changes after meniscectomy. J Bone Joint Surg Br 1948; 30: 164-170
    PubMedSearch in Google Scholar
  • 9 Cicuttini FM, Forbes A, Yuanyuan W, Rush G, Stuckey SL. Rate of knee cartilage loss after partial meniscectomy. J Rheumatol 2002; 29 (09) 1954-1956
    PubMedSearch in Google Scholar
  • 10 Englund M, Lohmander LS. Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum 2004; 50 (09) 2811-2819
    CrossrefPubMedSearch in Google Scholar
  • 11 Arnoczky SP, Warren RF. The microvasculature of the meniscus and its response to injury. An experimental study in the dog. Am J Sports Med 1983; 11 (03) 131-141
    CrossrefPubMedSearch in Google Scholar
  • 12 Arnoczky SP, Warren RF. Microvasculature of the human meniscus. Am J Sports Med 1982; 10 (02) 90-95
    CrossrefPubMedSearch in Google Scholar
  • 13 Chevrier A, Nelea M, Hurtig MB, Hoemann CD, Buschmann MD. Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair. J Orthop Res 2009; 27 (09) 1197-1203
    CrossrefPubMedSearch in Google Scholar
  • 14 Cannon Jr WD, Vittori JM. The incidence of healing in arthroscopic meniscal repairs in anterior cruciate ligament-reconstructed knees versus stable knees. Am J Sports Med 1992; 20 (02) 176-181
    CrossrefPubMedSearch in Google Scholar
  • 15 Angel MJ, Kerker J, Sgaglione N. Meniscus repair and future directions. In: McKeon BP, Bono JV, Richmond JC. , eds. Knee Arthroscopy. New York, NY: Springer Science+Business Media; 2009: 25-40
    CrossrefSearch in Google Scholar
  • 16 Pereira H, Cengiz IF, Correia JS. , et al. Meniscal repair: indications, techniques, and outcome. In: Randelli P, Dejour D, van Dijk CN, Denti M, Seil R. , eds. Arthroscopy, Basic to Advanced. Luxembourg: Springer; 2016: 125-142
    Search in Google Scholar
  • 17 Nepple JJ, Dunn WR, Wright RW. Meniscal repair outcomes at greater than five years: a systematic literature review and meta-analysis. J Bone Joint Surg Am 2012; 94 (24) 2222-2227
    CrossrefPubMedSearch in Google Scholar
  • 18 Pujol N, Panarella L, Selmi TAS, Neyret P, Fithian D, Beaufils P. Meniscal healing after meniscal repair: a CT arthrography assessment. Am J Sports Med 2008; 36 (08) 1489-1495
    CrossrefPubMedSearch in Google Scholar
  • 19 Gallacher PD, Gilbert RE, Kanes G, Roberts SN, Rees D. White on white meniscal tears to fix or not to fix?. Knee 2010; 17 (04) 270-273
    CrossrefPubMedSearch in Google Scholar
  • 20 Clayton RAE, Court-Brown CM. The epidemiology of musculoskeletal tendinous and ligamentous injuries. Injury 2008; 39 (12) 1338-1344
    CrossrefPubMedSearch in Google Scholar
  • 21 Widuchowski W, Widuchowski J, Trzaska T. Articular cartilage defects: study of 25,124 knee arthroscopies. Knee 2007; 14 (03) 177-182
    CrossrefPubMedSearch in Google Scholar
  • 22 Kim S, Bosque J, Meehan JP, Jamali A, Marder R. Increase in outpatient knee arthroscopy in the United States: a comparison of National Surveys of Ambulatory Surgery, 1996 and 2006. J Bone Joint Surg Am 2011; 93 (11) 994-1000
    CrossrefPubMedSearch in Google Scholar
  • 23 Snoeker BA, Bakker EW, Kegel CA, Lucas C. Risk factors for meniscal tears: a systematic review including meta-analysis. J Orthop Sports Phys Ther 2013; 43 (06) 352-367
    CrossrefPubMedSearch in Google Scholar
  • 24 Scotti C, Hirschmann MT, Antinolfi P, Martin I, Peretti GM. Meniscus repair and regeneration: review on current methods and research potential. Eur Cell Mater 2013; 26: 150-170
    PubMedSearch in Google Scholar
  • 25 Chung KS, Ha JK, Ra HJ, Kim JG. Prognostic factors in the midterm results of pullout fixation for posterior root tears of the medial meniscus. Arthroscopy 2016; 32 (07) 1319-1327
    CrossrefPubMedSearch in Google Scholar
  • 26 Moatshe G, Chahla J, Slette E, Engebretsen L, Laprade RF. Posterior meniscal root injuries. Acta Orthop 2016; 87 (05) 452-458
    CrossrefPubMedSearch in Google Scholar
  • 27 Chahla J, Dean CS, Moatshe G. , et al. Meniscal ramp lesions: anatomy, incidence, diagnosis, and treatment. Orthop J Sports Med 2016; 4 (07) 2325967116657815
    PubMedSearch in Google Scholar
  • 28 Thaunat M, Fayard JM, Guimaraes TM, Jan N, Murphy CG, Sonnery-Cottet B. Classification and surgical repair of ramp lesions of the medial meniscus. Arthrosc Tech 2016; 5 (04) e871-e875
    CrossrefPubMedSearch in Google Scholar
  • 29 Hutchinson ID, Moran CJ, Potter HG, Warren RF, Rodeo SA. Restoration of the meniscus: form and function. Am J Sports Med 2014; 42 (04) 987-998
    CrossrefPubMedSearch in Google Scholar
  • 30 van de Graaf VA, Wolterbeek N, Mutsaerts EL. , et al. Arthroscopic partial meniscectomy or conservative treatment for nonobstructive meniscal tears: a systematic review and meta-analysis of randomized controlled trials. Arthroscopy 2016; 32 (09) 1855-1865.e4
    CrossrefPubMedSearch in Google Scholar
  • 31 Khan M, Evaniew N, Bedi A, Ayeni OR, Bhandari M. Arthroscopic surgery for degenerative tears of the meniscus: a systematic review and meta-analysis. CMAJ 2014; 186 (14) 1057-1064
    CrossrefPubMedSearch in Google Scholar
  • 32 Mezhov V, Teichtahl AJ, Strasser R, Wluka AE, Cicuttini FM. Meniscal pathology - the evidence for treatment. Arthritis Res Ther 2014; 16 (02) 206
    CrossrefPubMedSearch in Google Scholar
  • 33 Monk P, Garfjeld Roberts P, Palmer AJ. , et al. The urgent need for evidence in arthroscopic meniscal surgery: a systematic review of the evidence for operative management of meniscal tears. Am J Sports Med 2016; 0363546516650180
    PubMedSearch in Google Scholar
  • 34 Noyes FR, Barber-Westin SD. Meniscus tears: diagnosis, repair techniques, and clinical outcomes. In: Noyes FR. , ed. Noye's Knee Disorders: Surgery, Rehabilitation, Clinical Outcomes. Philadelphia, PA: Saunders, an Imprint of Elsevier Inc.; 2010: 733-771
    Search in Google Scholar
  • 35 Katz LM, Weitzel PP. Partial meniscectomy. In: McKeon BP, Bono JV, Richmond JC. , eds. Knee Arthroscopy. New York, NY: Springer; 2009: 11-23
    CrossrefSearch in Google Scholar
  • 36 Kurzweil PR, Lynch NM, Coleman S, Kearney B. Repair of horizontal meniscus tears: a systematic review. Arthroscopy 2014; 30 (11) 1513-1519
    CrossrefPubMedSearch in Google Scholar
  • 37 Moulton SG, Bhatia S, Civitarese DM, Frank RM, Dean CS, LaPrade RF. Surgical techniques and outcomes of repairing meniscal radial tears: a systematic review. Arthroscopy 2016; 32 (09) 1919-1925
    CrossrefPubMedSearch in Google Scholar
  • 38 Rubman MH, Noyes FR, Barber-Westin SD. Arthroscopic repair of meniscal tears that extend into the avascular zone. A review of 198 single and complex tears. Am J Sports Med 1998; 26 (01) 87-95
    CrossrefPubMedSearch in Google Scholar
  • 39 Steadman JR, Matheny LM, Singleton SB. , et al. Meniscus suture repair: minimum 10-year outcomes in patients younger than 40 years compared with patients 40 and older. Am J Sports Med 2015; 43 (09) 2222-2227
    CrossrefPubMedSearch in Google Scholar
  • 40 Cavanaugh JT, Killian SE. Rehabilitation following meniscal repair. Curr Rev Musculoskelet Med 2012; 5 (01) 46-58
    CrossrefPubMedSearch in Google Scholar
  • 41 Bryant D, Dill J, Litchfield R. , et al. Effectiveness of bioabsorbable arrows compared with inside-out suturing for vertical, reparable meniscal lesions: a randomized clinical trial. Am J Sports Med 2007; 35 (06) 889-896
    CrossrefPubMedSearch in Google Scholar
  • 42 Albrecht-Olsen P, Kristensen G, Burgaard P, Joergensen U, Toerholm C. The arrow versus horizontal suture in arthroscopic meniscus repair. A prospective randomized study with arthroscopic evaluation. Knee Surg Sports Traumatol Arthrosc 1999; 7 (05) 268-273
    Search in Google Scholar
  • 43 Barber FA, Johnson DH, Halbrecht JL. Arthroscopic meniscal repair using the BioStinger. Arthroscopy 2005; 21 (06) 744-750
    CrossrefPubMedSearch in Google Scholar
  • 44 Choi NH, Kim TH, Victoroff BN. Comparison of arthroscopic medial meniscal suture repair techniques: inside-out versus all-inside repair. Am J Sports Med 2009; 37 (11) 2144-2150
    CrossrefPubMedSearch in Google Scholar
  • 45 Spindler KP, McCarty EC, Warren TA, Devin C, Connor JT. Prospective comparison of arthroscopic medial meniscal repair technique: inside-out suture versus entirely arthroscopic arrows. Am J Sports Med 2003; 31 (06) 929-934
    CrossrefPubMedSearch in Google Scholar
  • 46 Saliman JD. The circumferential compression stitch for meniscus repair. Arthrosc Tech 2013; 2 (03) e257-e264
    CrossrefPubMedSearch in Google Scholar
  • 47 Fillingham YA, Riboh JC, Erickson BJ, Bach Jr BR, Yanke AB. Inside-out versus all-inside repair of isolated meniscal tears. Am J Sports Med 2017; 45 (01) 234-242
    CrossrefPubMedSearch in Google Scholar
  • 48 Lozano J, Ma CB, Cannon WD. All-inside meniscus repair: a systematic review. Clin Orthop Relat Res 2007; 455 (455) 134-141
    CrossrefPubMedSearch in Google Scholar
  • 49 Westermann RW, Duchman KR, Amendola A, Glass N, Wolf BR. All-inside versus inside-out meniscal repair with concurrent anterior cruciate ligament reconstruction. Am J Sports Med 2017; 45 (03) 719-724
    CrossrefPubMedSearch in Google Scholar
  • 50 Grant JA, Wilde J, Miller BS, Bedi A. Comparison of inside-out and all-inside techniques for the repair of isolated meniscal tears: a systematic review. Am J Sports Med 2012; 40 (02) 459-468
    CrossrefPubMedSearch in Google Scholar
  • 51 Mutsaerts EL, van Eck CF, van de Graaf VA, Doornberg JN, van den Bekerom MP. Surgical interventions for meniscal tears: a closer look at the evidence. Arch Orthop Trauma Surg 2016; 136 (03) 361-370
    CrossrefPubMedSearch in Google Scholar
  • 52 Biedert RM. Treatment of intrasubstance meniscal lesions: a randomized prospective study of four different methods. Knee Surg Sports Traumatol Arthrosc 2000; 8 (02) 104-108
    CrossrefPubMedSearch in Google Scholar
  • 53 Stein T, Mehling AP, Welsch F, von Eisenhart-Rothe R, Jäger A. Long-term outcome after arthroscopic meniscal repair versus arthroscopic partial meniscectomy for traumatic meniscal tears. Am J Sports Med 2010; 38 (08) 1542-1548
    CrossrefPubMedSearch in Google Scholar
  • 54 Shelbourne KD, Dersam MD. Comparison of partial meniscectomy versus meniscus repair for bucket-handle lateral meniscus tears in anterior cruciate ligament reconstructed knees. Arthroscopy 2004; 20 (06) 581-585
    CrossrefPubMedSearch in Google Scholar
  • 55 Lutz C, Dalmay F, Ehkirch FP. , et al; French Arthroscopy Society. Meniscectomy versus meniscal repair: 10 years radiological and clinical results in vertical lesions in stable knee. Orthop Traumatol Surg Res 2015; 101 (8, Suppl): S327-S331
    CrossrefPubMedSearch in Google Scholar
  • 56 Xu C, Zhao J. A meta-analysis comparing meniscal repair with meniscectomy in the treatment of meniscal tears: the more meniscus, the better outcome?. Knee Surg Sports Traumatol Arthrosc 2015; 23 (01) 164-170
    CrossrefPubMedSearch in Google Scholar
  • 57 Paxton ES, Stock MV, Brophy RH. Meniscal repair versus partial meniscectomy: a systematic review comparing reoperation rates and clinical outcomes. Arthroscopy 2011; 27 (09) 1275-1288
    CrossrefPubMedSearch in Google Scholar
  • 58 Westermann RW, Wright RW, Spindler KP, Huston LJ, Wolf BR. ; MOON Knee Group. Meniscal repair with concurrent anterior cruciate ligament reconstruction: operative success and patient outcomes at 6-year follow-up. Am J Sports Med 2014; 42 (09) 2184-2192
    CrossrefPubMedSearch in Google Scholar
  • 59 Zhang ZN, Tu KY, Xu YK, Zhang WM, Liu ZT, Ou SH. Treatment of longitudinal injuries in avascular area of meniscus in dogs by trephination. Arthroscopy 1988; 4 (03) 151-159
    CrossrefPubMedSearch in Google Scholar
  • 60 Zhang Z, Arnold JA, Williams T, McCann B. Repairs by trephination and suturing of longitudinal injuries in the avascular area of the meniscus in goats. Am J Sports Med 1995; 23 (01) 35-41
    CrossrefPubMedSearch in Google Scholar
  • 61 Cook JL, Fox DB. A novel bioabsorbable conduit augments healing of avascular meniscal tears in a dog model. Am J Sports Med 2007; 35 (11) 1877-1887
    CrossrefPubMedSearch in Google Scholar
  • 62 Fox JM, Rintz KG, Ferkel RD. Trephination of incomplete meniscal tears. Arthroscopy 1993; 9 (04) 451-455
    CrossrefPubMedSearch in Google Scholar
  • 63 Zhang Z, Arnold JA. Trephination and suturing of avascular meniscal tears: a clinical study of the trephination procedure. Arthroscopy 1996; 12 (06) 726-731
    CrossrefPubMedSearch in Google Scholar
  • 64 Shelbourne KD, Rask BP. The sequelae of salvaged nondegenerative peripheral vertical medial meniscus tears with anterior cruciate ligament reconstruction. Arthroscopy 2001; 17 (03) 270-274
    CrossrefPubMedSearch in Google Scholar
  • 65 Shelbourne KD, Benner RW, Nixon RA, Gray T. Evaluation of peripheral vertical nondegenerative medial meniscus tears treated with trephination alone at the time of anterior cruciate ligament reconstruction. Arthroscopy 2015; 31 (12) 2411-2416
    CrossrefPubMedSearch in Google Scholar
  • 66 Okuda K, Ochi M, Shu N, Uchio Y. Meniscal rasping for repair of meniscal tear in the avascular zone. Arthroscopy 1999; 15 (03) 281-286
    CrossrefPubMedSearch in Google Scholar
  • 67 Ochi M, Uchio Y, Okuda K, Shu N, Yamaguchi H, Sakai Y. Expression of cytokines after meniscal rasping to promote meniscal healing. Arthroscopy 2001; 17 (07) 724-731
    CrossrefPubMedSearch in Google Scholar
  • 68 Uchio Y, Ochi M, Adachi N, Kawasaki K, Iwasa J. Results of rasping of meniscal tears with and without anterior cruciate ligament injury as evaluated by second-look arthroscopy. Arthroscopy 2003; 19 (05) 463-469
    CrossrefPubMedSearch in Google Scholar
  • 69 Tetik O, Kocabey Y, Johnson DL. Synovial abrasion for isolated, partial thickness, undersurface, medial meniscus tears. Orthopedics 2002; 25 (06) 675-678
    PubMedSearch in Google Scholar
  • 70 Talley MC, Grana WA. Treatment of partial meniscal tears identified during anterior cruciate ligament reconstruction with limited synovial abrasion. Arthroscopy 2000; 16 (01) 6-10
    PubMedSearch in Google Scholar
  • 71 Freedman KB, Nho SJ, Cole BJ. Marrow stimulating technique to augment meniscus repair. Arthroscopy 2003; 19 (07) 794-798
    CrossrefPubMedSearch in Google Scholar
  • 72 Ishimura M, Ohgushi H, Habata T, Tamai S, Fujisawa Y. Arthroscopic meniscal repair using fibrin glue. Part I: experimental study. Arthroscopy 1997; 13 (05) 551-557
    CrossrefPubMedSearch in Google Scholar
  • 73 Ishimura M, Tamai S, Fujisawa Y. Arthroscopic meniscal repair with fibrin glue. Arthroscopy 1991; 7 (02) 177-181
    CrossrefPubMedSearch in Google Scholar
  • 74 Ishimura M, Ohgushi H, Habata T, Tamai S, Fujisawa Y. Arthroscopic meniscal repair using fibrin glue. Part II: clinical applications. Arthroscopy 1997; 13 (05) 558-563
    CrossrefPubMedSearch in Google Scholar
  • 75 Ritchie JR, Miller MD, Bents RT, Smith DK. Meniscal repair in the goat model. The use of healing adjuncts on central tears and the role of magnetic resonance arthrography in repair evaluation. Am J Sports Med 1998; 26 (02) 278-284
    CrossrefPubMedSearch in Google Scholar
  • 76 Port J, Jackson DW, Lee TQ, Simon TM. Meniscal repair supplemented with exogenous fibrin clot and autogenous cultured marrow cells in the goat model. Am J Sports Med 1996; 24 (04) 547-555
    CrossrefPubMedSearch in Google Scholar
  • 77 Nakhostine M, Gershuni DH, Danzig LA. Effects of an in-substance conduit with injection of a blood clot on tears in the avascular region of the meniscus. Acta Orthop Belg 1991; 57 (03) 242-246
    PubMedSearch in Google Scholar
  • 78 van Trommel MF, Simonian PT, Potter HG, Wickiewicz TL. Arthroscopic meniscal repair with fibrin clot of complete radial tears of the lateral meniscus in the avascular zone. Arthroscopy 1998; 14 (04) 360-365
    CrossrefPubMedSearch in Google Scholar
  • 79 Jang SH, Ha JK, Lee DW, Kim JG. Fibrin clot delivery system for meniscal repair. Knee Surg Relat Res 2011; 23 (03) 180-183
    CrossrefPubMedSearch in Google Scholar
  • 80 Ra HJ, Ha JK, Jang SH, Lee DW, Kim JG. Arthroscopic inside-out repair of complete radial tears of the meniscus with a fibrin clot. Knee Surg Sports Traumatol Arthrosc 2013; 21 (09) 2126-2130
    CrossrefPubMedSearch in Google Scholar
  • 81 Kamimura T, Kimura M. Repair of horizontal meniscal cleavage tears with exogenous fibrin clots. Knee Surg Sports Traumatol Arthrosc 2011; 19 (07) 1154-1157
    CrossrefPubMedSearch in Google Scholar
  • 82 Kamimura T, Kimura M. Meniscal repair of degenerative horizontal cleavage tears using fibrin clots: clinical and arthroscopic outcomes in 10 cases. Orthop J Sports Med 2014; 2 (11) 2325967114555678
    PubMedSearch in Google Scholar
  • 83 Sethi PM, Cooper A, Jokl P. Technical tips in orthopaedics: meniscal repair with use of an in situ fibrin clot. Arthroscopy 2003; 19 (05) E44
    PubMedSearch in Google Scholar
  • 84 Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol 2013; 9 (12) 721-730
    CrossrefPubMedSearch in Google Scholar
  • 85 Braun HJ, Wasterlain AS, Dragoo JL. The use of PRP in ligament and meniscal healing. Sports Med Arthrosc Rev 2013; 21 (04) 206-212
    CrossrefPubMedSearch in Google Scholar
  • 86 Ishida K, Kuroda R, Miwa M. , et al. The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. Tissue Eng 2007; 13 (05) 1103-1112
    CrossrefPubMedSearch in Google Scholar
  • 87 Zellner J, Mueller M, Berner A. , et al. Role of mesenchymal stem cells in tissue engineering of meniscus. J Biomed Mater Res A 2010; 94 (04) 1150-1161
    PubMedSearch in Google Scholar
  • 88 Zellner J, Hierl K, Mueller M. , et al. Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone. J Biomed Mater Res B Appl Biomater 2013; 101 (07) 1133-1142
    CrossrefPubMedSearch in Google Scholar
  • 89 Shin KH, Lee H, Kang S. , et al. Effect of leukocyte-rich and platelet-rich plasma on healing of a horizontal medial meniscus tear in a rabbit model. BioMed Res Int 2015; 2015 (15) 179756
    PubMedSearch in Google Scholar
  • 90 Lee HR, Shon OJ, Park SI. , et al. Platelet-rich plasma increases the levels of catabolic molecules and cellular dedifferentiation in the meniscus of a rabbit model. Int J Mol Sci 2016; 17 (01) E120
    CrossrefPubMedSearch in Google Scholar
  • 91 Pujol N, Salle De Chou E, Boisrenoult P, Beaufils P. Platelet-rich plasma for open meniscal repair in young patients: any benefit?. Knee Surg Sports Traumatol Arthrosc 2015; 23 (01) 51-58
    CrossrefPubMedSearch in Google Scholar
  • 92 Griffin JW, Hadeed MM, Werner BC, Diduch DR, Carson EW, Miller MD. Platelet-rich plasma in meniscal repair: does augmentation improve surgical outcomes?. Clin Orthop Relat Res 2015; 473 (05) 1665-1672
    CrossrefPubMedSearch in Google Scholar
  • 93 Henning CE, Lynch MA, Yearout KM, Vequist SW, Stallbaumer RJ, Decker KA. Arthroscopic meniscal repair using an exogenous fibrin clot. Clin Orthop Relat Res 1990; (252) 64-72
    PubMedSearch in Google Scholar
  • 94 Henning CE, Yearout KM, Vequist SW, Stallbaumer RJ, Decker KA. Use of the fascia sheath coverage and exogenous fibrin clot in the treatment of complex meniscal tears. Am J Sports Med 1991; 19 (06) 626-631
    CrossrefPubMedSearch in Google Scholar
  • 95 Barrett GR, Treacy SH. Use of the T-fix suture anchor in fascial sheath reconstruction of complex meniscal tears. Arthroscopy 1996; 12 (02) 251-255
    CrossrefPubMedSearch in Google Scholar
  • 96 Jacobi M, Jakob RP. Meniscal repair: enhancement of healing process. In: Beaufils P, Verdonk R. , eds. The Meniscus. London, New York, Berlin, Heidelberg: Springer-Verlag; 2010
    Search in Google Scholar
  • 97 Jülke H, Mainil-Varlet P, Jakob RP, Brehm W, Schäfer B, Nesic D. The role of cells in meniscal guided tissue regeneration: a proof of concept study in a goat model. Cartilage 2015; 6 (01) 20-29
    CrossrefPubMedSearch in Google Scholar
  • 98 Piontek T, Ciemniewska-Gorzela K, Szulc A, Słomczykowski M, Jakob R. All-arthroscopic technique of biological meniscal tear therapy with collagen matrix. Chir Narzadow Ruchu Ortop Pol 2012; 77: 39-45
    PubMedSearch in Google Scholar
  • 99 Piontek T, Ciemniewska-Gorzela K, Naczk J. , et al. Complex meniscus tears treated with collagen matrix wrapping and bone marrow blood injection: a 2-year clinical follow-up. Cartilage 2016; 7 (02) 123-139
    CrossrefPubMedSearch in Google Scholar
  • 100 Iliescu M, Hoemann CD, Shive MS, Chenite A, Buschmann MD. Ultrastructure of hybrid chitosan-glycerol phosphate blood clots by environmental scanning electron microscopy. Microsc Res Tech 2008; 71 (03) 236-247
    CrossrefPubMedSearch in Google Scholar
  • 101 Hoemann CD, Sun J, McKee MD. , et al. Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects. Osteoarthritis Cartilage 2007; 15 (01) 78-89
    CrossrefPubMedSearch in Google Scholar
  • 102 Hoemann CD, Hurtig M, Rossomacha E. , et al. Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects. J Bone Joint Surg Am 2005; 87 (12) 2671-2686
    CrossrefPubMedSearch in Google Scholar
  • 103 Chevrier A, Hoemann CD, Sun J, Buschmann MD. Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects. Osteoarthritis Cartilage 2007; 15 (03) 316-327
    CrossrefPubMedSearch in Google Scholar
  • 104 Hoemann CD, Chen G, Marchand C. , et al. Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages. Am J Sports Med 2010; 38 (09) 1845-1856
    CrossrefPubMedSearch in Google Scholar
  • 105 Chen G, Sun J, Lascau-Coman V, Chevrier A, Marchand C, Hoemann CD. Acute osteoclast activity following subchondral drilling is promoted by Chitosan and associated with improved cartilage repair tissue integration. Cartilage 2011; 2 (02) 173-185
    CrossrefPubMedSearch in Google Scholar
  • 106 Fong D, Ariganello MB, Girard-Lauzière J, Hoemann CD. Biodegradable chitosan microparticles induce delayed STAT-1 activation and lead to distinct cytokine responses in differentially polarized human macrophages in vitro. Acta Biomater 2015; 12: 183-194
    CrossrefPubMedSearch in Google Scholar
  • 107 Chevrier A, Darras V, Picard G. , et al. Injectable chitosan-platelet-rich plasma (PRP) implants to promote tissue regeneration: in vitro properties, in vivo residence, degradation, cell recruitment and vascularization. J Tissue Eng Regen Med 2017;
    PubMedSearch in Google Scholar
  • 108 Chevrier A, Deprés-Tremblay G, Hurtig MB. , et al. Chitosan-platelet-rich plasma implants can be injected into meniscus defects to improve repair. Paper presented at the Orthopaedic Research Society; Orlando, FL; March 5–8, 2016
    PubMedSearch in Google Scholar
  • 109 Ghazi zadeh L, Chevrier A, Hurtig MB. , et al. Freeze-dried chitosan-PRP implants improve meniscus repair in an ovine model. Paper presented at the International Cartilage Repair Society; Sorrento, Italy; September 24–27, 2016
    PubMedSearch in Google Scholar
  • 110 Mordecai SC, Al-Hadithy N, Ware HE, Gupte CM. Treatment of meniscal tears: an evidence based approach. World J Orthop 2014; 5 (03) 233-241
    CrossrefPubMedSearch in Google Scholar
  • 111 Kise NJ, Drogset JO, Ekeland A, Sivertsen EA, Heir S. All-inside suture device is superior to meniscal arrows in meniscal repair: a prospective randomized multicenter clinical trial with 2-year follow-up. Knee Surg Sports Traumatol Arthrosc 2015; 23 (01) 211-218
    CrossrefPubMedSearch in Google Scholar
  • 112 Hantes ME, Zachos VC, Varitimidis SE, Dailiana ZH, Karachalios T, Malizos KN. Arthroscopic meniscal repair: a comparative study between three different surgical techniques. Knee Surg Sports Traumatol Arthrosc 2006; 14 (12) 1232-1237
    CrossrefPubMedSearch in Google Scholar
  • 113 Järvelä S, Sihvonen R, Sirkeoja H, Järvelä T. All-inside meniscal repair with bioabsorbable meniscal screws or with bioabsorbable meniscus arrows: a prospective, randomized clinical study with 2-year results. Am J Sports Med 2010; 38 (11) 2211-2217
    CrossrefPubMedSearch in Google Scholar
  • 114 Shelbourne KD, Heinrich J. The long-term evaluation of lateral meniscus tears left in situ at the time of anterior cruciate ligament reconstruction. Arthroscopy 2004; 20 (04) 346-351
    CrossrefPubMedSearch in Google Scholar