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Semin Thromb Hemost 2017; 43(05): 447-448
DOI: 10.1055/s-0037-1602661
Preface
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Clinical Scoring Systems in Thrombosis and Hemostasis

Adam Cuker
1   Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
2   Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
› Author Affiliations
Further Information

Address for correspondence

Adam Cuker, MD, MS
Hospital of the University of Pennsylvania
3400 Spruce Street, Philadelphia, PA 19104

Publication History

Publication Date:
23 June 2017 (online)

 
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Welcome to this special theme issue of Seminars in Thrombosis & Hemostasis on “clinical scoring systems in thrombosis and hemostasis.” Clinical scoring systems (CSSs) are known by many other names including clinical prediction rules, clinical decision rules, probability assessments, prediction models, and risk scores.[1] No matter which term is used, CSSs are tools that quantify the individual contributions that various components of the history, physical examination, and basic laboratory investigation make toward a patient's diagnosis or prognosis.[2] Although CSSs may be used as research tools (e.g., as a means of defining whether subjects have a disease of interest or quantifying their risk of a certain outcome), they are first and foremost intended to improve clinical care by standardizing, simplifying, and improving the accuracy of clinicians' diagnostic or prognostic assessments.

Development of CSSs includes four key steps: (1) derivation, (2) validation, (3) impact analysis, and (4) implementation.[1] [2] In the derivation step, a comprehensive list of items from the history, physical examination, and basic investigation with potential predictive power is constructed. A group of patients (the derivation cohort) is studied to determine whether the candidate variables predict the outcome of interest. Statistical analysis reveals which predictors are most powerful and should be included in the CSS and which may be omitted without loss of predictive power. In the second step, the performance of the CSS must be validated in a separate population (the validation cohort). The most useful CSSs perform well not only in populations similar to the derivation cohort but also in broad clinical settings with a varying prevalence of the outcome of interest. After a CSS has been validated, its use must be shown to change clinician behavior and improve patient outcomes and/or reduce costs compared with standard of care. Typical study designs used for such impact analyses include randomization of administrative units to the application or nonapplication of the CSS or pre- versus postimplementation studies. Even if a CSS is shown to have a favorable effect on patient outcomes or resource utilization in an impact analysis, there is no guarantee that practitioners will adopt it. Several potential barriers to the adoption of CSSs exist. Clinicians may be unaware of the existence of a CSS, or CSSs may be complex, cumbersome to use, or hard to remember. Or clinicians may distrust a CSS when it conflicts with their clinical judgment. As such, the final step in the development of a CSS is to evaluate whether it has been accepted and adopted in real-world clinical practice. Many CSSs have been derived and validated (steps 1 and 2), but comparatively, few have been tested in an impact analysis or enjoyed widespread adoption (steps 3 and 4).[1] [2]

The number of published CSSs has grown tremendously in recent years. A Medline search by Toll et al found that the number of articles on CSSs more than doubled between 1995 and 2005 (6,744 vs. 15,662).[3] A recent systematic review identified 434 unique CSSs pertinent to primary care alone.[4] Some CSSs such as APACHE (Acute Physiology and Chronic Health Evaluation) II, the MELD (Model of End-Stage Liver Disease) score, Pneumonia Severity Index, Ranson criteria, and Glasgow Coma Scale have become part of the daily lexicon in hospital wards and clinics throughout the world.[5] [6] [7] [8] [9] However, the sheer number of CSSs available to clinicians is both potentially helpful and inhibitory for their adoption.

The field of thrombosis and hemostasis has not been immune to the proliferation of CSSs. This theme issue includes 12 articles on the application of CSSs to various disorders of bleeding and clotting. Each article reviews available CSSs, where they stand in the four-step development process, their strengths and limitations, and their applicability (real or potential) to clinical practice.

Several articles are devoted to the use of CSSs for venous thromboembolism (VTE). The first three articles focus on CSSs for estimating the risk of VTE in surgical patients,[10] hospitalized medical patients,[11] and patients with cancer.[12] The next article summarizes the role of CSSs in diagnostic pathways for VTE.[13] CSSs have also been developed to inform key management issues in VTE. Prognostic CSSs for acute pulmonary embolism may be used to determine whether a patient is appropriate for outpatient therapy.[14] CSSs for estimating the risk of recurrent VTE may be used to guide decisions regarding the duration of anticoagulation.[15] Finally, CSSs have been developed for diagnosis of postthrombotic syndrome, a common complication of deep vein thrombosis.[16]

VTE is not the only thrombotic disorder to which CSSs may be applied. CSSs are widely used for estimating stroke risk in patients with atrial fibrillation.[17] The potential benefit of anticoagulation to reduce stroke risk in patients with atrial fibrillation must be balanced against the potential harms of bleeding. Several CSSs have been developed to estimate the risk of anticoagulant-associated bleeding.[18] Another article in this issue focuses not on a specific disorder but on a specific predictive variable, ABO blood type, and its role in CSSs for thrombotic disorders.[19]

CSSs have a lesser but nonetheless growing presence in the diagnosis of bleeding and platelet disorders. Bleeding scores are an important research tool and have now entered the clinic as a means of identifying patients with possible bleeding disorders (e.g., von Willebrand disease).[20] Recent work has also led to development of CSSs intended to aid in differentiating thrombotic thrombocytopenic purpura from other forms of thrombotic microangiopathy.[21]

As CSSs continue to permeate the medical literature and clinical practice in thrombosis and hemostasis, it is hoped that readers find this special theme issue timely, informative, and enjoyable.


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No conflict of interest has been declared by the author(s).

Disclosure

A.C. has served as a consultant for Biogen-Idec, Diagnostica Stago, and Genzyme and has received research support from Biogen-Idec, Spark Therapeutics, and T2 Biosystems.


Address for correspondence

Adam Cuker, MD, MS
Hospital of the University of Pennsylvania
3400 Spruce Street, Philadelphia, PA 19104


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