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DOI: 10.1055/s-0037-1603643
Neurological Involvement in Pediatric Hemolytic Uremic Syndrome: A Symptom-Oriented Analysis
Publication History
01 February 2017
24 April 2017
Publication Date:
01 June 2017 (online)
Abstract
Background Neurological involvement is common in hemolytic uremic syndrome (HUS), but each neurological symptom may be due to a variety of factors.
Objective We aimed to evaluate predisposing factors to the neurological symptoms in HUS.
Materials and Methods The 10-year follow-up data on HUS patients were retrospectively analyzed. Statistical comparisons were made across subgroups based on age and neurological symptoms.
Results The neurological involvement rate was 37.5%. The female-to-male ratio increased in patients with neurological involvement (3.8 vs. 1.37). Regarding all HUS patients, hemoglobin levels were higher in patients with paresis. The rate of paresis was twofold higher in patients with a hemoglobin level above 11 g/dL (p < 0.05). In diarrhea-associated HUS patients, D-dimer and C-reactive protein levels were higher in patients with paresis, and leukocyte counts were higher in patients with seizures. Patients with altered consciousness had higher creatinine levels. The survival rate was significantly lower in patients with a reticulocyte percentage of less than 2% (50 vs. 100%).
Conclusion Results of our study indicate that neurological involvement depends on overall findings in HUS. A symptom-oriented approach, which is different from that employed in previous studies, reveals some clues to the pathogenesis and management of these patients.
Disclosures
The authors state that they have no interests that might be perceived as posing a conflict or bias. They received no financial support for the research, authorship, and/or publication of this article.