Abstract
Ischemic conditioning induced by nonlethal cycles of tissue ischemia and reperfusion
attenuates ischemia–reperfusion injury. The objective of this study is to systematically
review the effects of local and remote ischemic conditioning on laboratory parameters
of hemostasis and the clinical outcomes of thromboembolism or bleeding in patients
undergoing surgery or cardiac procedures. PubMed and Embase were searched for relevant
human trials published in English between January 1, 1986, and September 7, 2016,
and additional studies were identified from reference lists. Data on laboratory parameters
of hemostasis, thromboembolism, and bleeding were extracted for qualitative synthesis.
In total, 69 studies were included; of these, 53 were randomized controlled trials
(RCTs) and 11 were meta-analyses. Local and remote ischemic conditioning reduced platelet
activation in patients undergoing cardiac procedures. Local ischemic conditioning
did not reduce the thromboembolic risk in patients undergoing surgery or cardiac procedures.
Remote ischemic conditioning reduced the incidence of arterial thromboembolism after
surgery or cardiac procedures in 3 out of 28 RCTs and 4 out of 5 meta-analyses. Local
and remote ischemic conditioning did not increase operative bleeding. In conclusion,
ischemic conditioning reduced platelet activity without increasing the risk of bleeding
in patients undergoing surgery or cardiac procedures. Limited evidence supports the
proposal that ischemic conditioning reduces the incidence of arterial thromboembolism
in patients undergoing surgery or cardiac procedures.
Keywords
ischemic conditioning - hemostasis - thromboembolism - bleeding - surgery
