Antifungal Activity against Pythium insidiosum of Compounds from Scaevola taccada

J Suthiwong; C Yenjai; Y Thongsri

doi:10.1055/s-0037-1608141

Planta Medica International Open, Table of Contents

Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608141

Poster Session

Georg Thieme Verlag KG Stuttgart · New York

Antifungal Activity against Pythium insidiosum of Compounds from Scaevola taccada

J Suthiwong

¹Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand

,

C Yenjai

¹Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand

,

Y Thongsri

²Cellular and Molecular Immunology Research Unit (CMIRU), Department of Medical Technology, Faculty of Allied Health Science, Naresuan University, Phitsanulok, Thailand

› Author Affiliations

Abstract

Full Text

A new coumarin, scataccanol (1) and ten known compounds, including five coumarins; ent-ammirin (2), nodachenetin (3), marmesin (4), xanthyletin (5) and umbelliferone (6), a benzaldehyde derivative; 4-formylsyringol(7), two iridoids; 6-hydroxy-7-methyl-1-oxo-4-carbomethoxy octahydro-cyclopenta[c]pyran (8) and loganetin (9), a lignan; matairesinol (10) and a cinnamoyl ester; 2-(4-hydroxyphenyl) 3-(3,4-dihydroxyphenyl)-2-propenoate (11) were isolated from the fruits of Scaevola taccada (Gaertn.) Roxb [1]. All compounds were evaluated for antifungal activity against Pythium insidiosum [2]. Xanthyletin (5) and 4-formylsyringol (7) showed strong antifungal activity with minimum inhibitory concentration values of 5 and 10 µg/mL, respectively [3]. Structural determination of all compounds was accomplished by 1D and 2D-NMR, IR and MS.

Fig. 1

[1] Ruangrungsi N, Mangkhla KT. Thai herbs, 1st edition. Thailand: Than Printing Company Limited; 2004: 259.

[2] Fonseca AOS, Pereira DIB, Jacob RG, Maia Filho FS, Oliveira DH, Maroneze BP, Valente JSS, Osório LG, Botton SA, Meireles MCA. Mycopathologia 2015; 179: 253 – 258.

[3] Suthiwong J, Thongsri Y, Yenjai C. Nat Prod Res 2017; 31: 453 – 459.

Figures

Fig. 1