Oligostilbenoids from Dipterocarpus cornutus

Dipterocarpus or commonly known as 'keruing' is an important source of dammarane, which contributes to a highly valued economic plant in Southeast Asia [1]. Preliminary study revealed that this plant is proven to produce a variety of chemical constituents such as volatile oil, triterpenoid, flavonoid, arylpropanoid, and oligomeric resveratrol [2]. Thus, in our continuing investigation on this family we wish to report the stem bark of D. cornutus which was subjected to explore more phytochemical constituents. The samples were collected from UiTM Jengka Forest Reserve, Pahang and extracted in methanol and acetone via cold maceration method. Isolation was done using multiple techniques of chromatography and the structural elucidation of the compounds were characterized using spectroscopic techniques as well as literary comparison. Phytochemical investigation led to the discovery of six oligostilbenoids namely davidiol A (1) and stenophyllol B (2), which were the first occurrence in Dipterocarpus genus along with hemsleyanol D (3), ε-viniferin (4), laevifonol (5) as well as ampelopsin F (6).

Greatest appreciation to Society for Medicinal Plant and Natural Product Research for the GA travel grant, MOHE for the SLAB-UITM scholarship and research grant (RAGS/1/2014/SG01/UITM/4) as well as Faculty of Applied Sciences for the financial support.

[1] Symington CF. Foresters' Manual of Dipterocarps. Kuala Lumpur: University Malaya Publication; 1974: 1 – 356.

[2] Wibowo A, Ahmat N. Biochemical Systematics and Ecology 2015; 59: 31 – 35