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DOI: 10.1055/s-0037-1608254
Miscellaneous phenolic compounds from Peucedanum chryseum (Boiss. & Heldr.) Chamberlain
Publication History
Publication Date:
24 October 2017 (online)
The genus Peucedanum (Apiaceae) comprising more than 120 species that are distributed in Europe, Asia, Africa and North America and 21 species with 42% endemism in the Flora of Turkey [1,2]. Peucedanum species have been used in traditional folk medicine for treatment of various ailments such as cough, cramps, pain, rheumatism, asthma and angina. There are several records on the chemistry of essential oil of the genus and different classes of coumarins, flavonoids and simple phenolics were reported from the genus. Previously only monoterpene hydrocarbons and fatty acids were isolated from Peucedanum chryseum (Boiss. & Heldr.) Chamberlain [3]. In this study, Peucedanum chryseum, an endemic specie for Turkey was phytochemically investigated for its phenolic compounds. The methanolic extracts of P. chryseum was first suspended in water and partitioned with n-hexane, chloroform and n-BuOH respectively. Further chromatographic analyzes of n-BuOH sub-extract was led to the isolation of four phenolic compounds (1 – 4): a phloroacetophenone glycoside A (1), a linear dihydropyrano chromon; cimifugin (2), a 1,3,6,8 tetrahydroxy xhanthone (3) and a benzoyl quercetin glycoside (4). The structures of the compounds were elucidated by extensive 1D-and 2D-NMR spectroscopic analysis in combination with MS experiments and comparing with relevant literature[4 – 6]. To our knowledge all these phenolic compounds were reported from the genus Peucedanum for the first time.
[1] Sarkhail P. Journal of Ethnopharmacology 2014; 156: 235 – 270.
[2] Davis PH. Flora of Turkey and East Aegean Islands. Edinburgh: University Press; 4: 475 – 476.
[3] Ağalar HG, Kürkçüoğlu M, Duran A, Çetin Ö, Başer KHC. Natural Volatiles & Essential Oils 2015; 2: 4 – 10.
[4] Chosson E, Chaboud A, Chulia AJ, Raynaud J. Phytochemistry 1998; 47: 87 – 88.
[5] Sasaki H, Taguchi H, Endo T, Yosioka I. Chemical and Pharmaceutical Bulletin 1982; 30: 3555 – 3562.
[6] Elix JA, Gaul KL, Lumbsch HT. Australian Journal of Chemistry 1987; 40: 1031 – 1033.
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