Lysimachia christinae Hance was traditionally used as Chinese traditional medicine. It is known to ease off the hyperuricemia and possess antipyretic and anti-inflammatory activity. Excessive glutamate contributes to excitotoxicity in brain and this can be etiological cause of the neurodegenerative diseases. The purpose of the study was to determine the neuroprotective effect of 80% methanol extract of Lysimachia christinae Hance against glutamate-induced oxidative stress in HT22 cells. In this experiment, intracelluar concentration of ROS and Ca2+ was decreased against glutamate treatment and this kept the normal mitochondrial membrane potential level. In addition, total glutathione amount and glutathione related antioxidant enzymes activities are increased. Through the whole mechanisms, Lysimachia christinae Hance significantly survived at the cell viability test. Consequently, Lysimachia christinae Hance is expected to be a good neuroprotective material.
