Thrombosis have an important role in cardiovascular [1]. Our recent study demonstrates the potential effect of sappan wood and ginger to inhibit platelet function for the prevention of thrombosis [2]. This study aims to investigate the efficacy of the mixture of sappan wood and ginger, and their interaction with Aspirin on the thrombosis model mice. Mice were divided into two experimental models. The acute pulmonary thromboembolism model was obtained by an intravenous injection of collagen and epinephrine. The efficacy and interaction was analysed by measuring bleeding time and survival rate. The mixture of sappan wood and ginger significantly prolonged the mouse tail bleeding time of mice but did not raise bleeding risk when combined with aspirin. They prevented death caused by pulmonary thrombosis and showed potentiate to enhance the antithrombotic effect of Aspirin. This study suggest that the mixture of sappan wood and ginger may be one of the promising herb for preventing thrombosis and have potentiate the antithrombotic effect of aspirin without raising bleeding risk.
Ministry of Research, Technology and Higher Education of Indonesia for financial support (Research Grand 2017)
[1] Kang WS, Lim IH, Yuk DY, Chung KH, Park JB, Yoo HS, Yun YP. Thrombosis Res 1999; 96: 229 – 237.
[2] Saputri FC, Nabila N, Mun'im A. J Young Pharm 2017; 9: 46 – 48.
