A convenient strategy has been developed for the synthesis of structurally diverse novel 1,4-dihydropyridine frameworks bearing a 3-nitrophenyl moiety through a one-pot, four-component reaction with 4-(N,N-dimethylamino)pyridine as a catalyst at room temperature. This tandem process proceeds more effectively than previous catalytic processes.
Key words
dimethylaminopyridine - nitrophenyldihydropyridines - multicomponent reactions - nitriles - amines - organocatalysis