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Synthesis 2018; 50(21): 4254-4262
DOI: 10.1055/s-0037-1610192
DOI: 10.1055/s-0037-1610192
feature
Chemoselective Organoclick–Click Sequence
Further Information
Publication History
Received: 16 May 2018
Accepted: 17 May 2018
Publication Date:
19 July 2018 (online)
Published as part of the Special Section on the 26th French–Japanese Symposium on Medicinal and Fine Chemistry
Abstract
A highly chemoselective bis-triazole synthesis based on a sequence organocatalyzed click reaction/copper-catalyzed click reaction is described in this paper. A range of bis-azides react with various ketones using proline catalysis through the aryl azide moiety while the alkyl azide one remains available for a metal-catalyzed triazole synthesis.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610192.
- Supporting Information
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