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Synlett 2018; 29(20): 2623-2632
DOI: 10.1055/s-0037-1610249
DOI: 10.1055/s-0037-1610249
account
Total Syntheses of Spinosyn A
We thank NSF (CAREER 1553820) for financial support. M.D. thanks Eli Lilly for an unrestricted grant support via the Eli Lilly Grantee Award.Further Information
Publication History
Received: 29 June 2018
Accepted after revision: 20 July 2018
Publication Date:
07 September 2018 (online)
Abstract
Spinosyn A is an important polycyclic natural product with impressive insecticidal activity and has been used worldwide in agriculture as the major component of Spinosad. Herein, four chemical total syntheses of spinosyn A are summarized. Its biosynthesis and a chemoenzymatic total synthesis are discussed as well.
1 Biosynthesis
2 The Evans Synthesis
3 The Paquette Synthesis
4 The Roush Synthesis
5 The Liu Synthesis
6 The Dai Synthesis
7 Conclusions
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