Subscribe to RSS
DOI: 10.1055/s-0037-1610751
FAST Hydrogenations as a Continuous Platform for Green Aromatic Nitroreductions
The authors gratefully acknowledge the financial support from Innovate UK under the Knowledge Transfer Partnership (KTP) programme for KTP Associate funding for MDTR for the project ‘Flow-mediated Amine Synthesis Technology Platform’.Publication History
Received: 03 December 2019
Accepted after revision: 27 January 2020
Publication Date:
13 February 2020 (online)


Published as part of the ISySyCat2019 Special Issue
Abstract
A continuous-flow packed-bed catalytic reactor has been developed for hydrogenation of aromatic nitrobenzoic acids in water to produce the corresponding anilines. These hydrogenations are green, more efficient, less consumptive, and safer than the conventional reduction process. Various industrially important aromatic amines have been produced in excellent yields and with high throughput. The optimized continuous-flow reduction process produces no detectable genotoxic intermediates, unlike the corresponding batch reduction. The reactor is modular in design and can be scaled up to produce several kilograms of product per day without extensive redesign.
Keywords
green chemistry - catalytic hydrogenation - continuous-flow packed-bed reactor - nitrobenzoic acids - anilinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610751.
- Supporting Information