Recyclable Pd₂dba₃/XPhos/PEG-2000 System for Efficient Boryl­ation of Aryl Chlorides: Practical Access to Aryl Boronates

Abstract

Pd₂dba₃/XPhos in poly(ethylene glycol) (PEG-2000) is shown to be a highly stable and efficient catalyst for the borylation of aryl chlorides with bis(pinacolato)diboron. The borylation reaction proceeds smoothly at 110 °C, delivering a wide variety of aryl boronates in good to excellent yields with high functional group tolerance. The crude products were easily isolated via simple extraction of the reaction mixture with cyclohexane. Moreover, both expensive Pd₂dba₃ and XPhos in PEG-2000 system could be readily recycled and reused more than six times without loss of catalytic efficiency.

Key words

palladium - borylation - aryl chloride - poly(ethylene glycol) - catalyst recycling

Publication History

Received: 12 September 2021

Accepted after revision: 14 October 2021

Article published online:
22 November 2021

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