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Synlett 2018; 29(18): 2444-2448
DOI: 10.1055/s-0037-1611062
DOI: 10.1055/s-0037-1611062
letter
Direct Conversion of Benzyl Ethers into Aryl Nitriles
The authors would like to thank the Program for Science and Technology Innovation Talents in Universities of Henan Province (Grant No.15HASTIT004) and the Open Project of State Key Laboratory for Oxo Synthesis and Selective Oxidation (Grant No. OSSO-2015-21) for financial support.Further Information
Publication History
Received: 24 August 2018
Accepted after revision: 21 September 2018
Publication Date:
16 October 2018 (online)
Abstract
A direct method was developed for the conversion of benzyl ethers into aryl nitriles by using NH4OAc as the nitrogen source and oxygen as the terminal oxidant with catalysis by TEMPO/HNO3; the method is valuable for both the synthesis of aromatic nitriles and for the deprotection of ether-protected hydroxy groups to form nitrile groups in multistep organic syntheses.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611062.
- Supporting Information
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For recent reviews on the preparation of aromatic nitriles, see: