Relationships between Homocysteine, Folate and Vitamin B12 Levels with the Methylenetetrahydrofolate Reductase Polymorphism, in Indians from Western Venezuela

Gilberto Vizcaíno; María Diez-Ewald; Falko H. Herrmann; Gudrun Schuster; José Luis Pérez-Requejo

doi:10.1055/s-0037-1612928

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 85(01): 186-187
DOI: 10.1055/s-0037-1612928

Letters to the Editor

Schattauer GmbH

Relationships between Homocysteine, Folate and Vitamin B12 Levels with the Methylenetetrahydrofolate Reductase Polymorphism, in Indians from Western Venezuela

Gilberto Vizcaíno

¹Instituto de Investigaciones Clínicas, Facultad de Medicina, La Universidad del Zulia, Maracaibo, Venezuela

,

María Diez-Ewald

¹Instituto de Investigaciones Clínicas, Facultad de Medicina, La Universidad del Zulia, Maracaibo, Venezuela

,

Falko H. Herrmann

²Institute of Human Genetics, Greifswald, Germany

,

Gudrun Schuster

²Institute of Human Genetics, Greifswald, Germany

,

José Luis Pérez-Requejo

³Banco de Sangre del Estado Carabobo, Valencia, Venezuela

› Author Affiliations

Abstract

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References

References
1 Goyette P, Christensen B, Rosenblatt DS, Rozen R. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR. Am J Hum Genet 1996; 59: 1268-75.
2 Engbersen AM, Franken DG, Boers GJ, Stevens EM, Trijbels FJ, Blom HJ. Thermolabile 5,10 methylenetetrahydrofalate reductase as a cause of mild hyperhomocystenemia. Am J Hum Genet 1995; 56: 142-50.
3 Jaques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations. Circulation 1996; 93: 7-9.
4 Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Eng J Med 1991; 324: 1149-55.
5 Dunn J, Title LM, Bata I, Johnstone DE, Kirkland SA, O’Neill BJ, Zayed E, MacDonald MC, Dempsey G, Nassar B. Relation of a common mutation in methylenetetrahydrofolate reductase to plasma homocysteine and early onset coronary artery disease. Clin Biochem 1998; 31: 95-100.
6 Salazar Sanchez L, Schröder W, Vizcaíno G, Pérez-Requejo JL, Jiménez G, Grimm R, Herrmann FH. The prevalence of three molecular risk factors (G20210A, C677T MTHFR, Factor V Leiden) in various ethnic groups in Costa Rica and Venezuela. Thromb Haemost 1999; 82 suppl 275.
7 Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, Rozen R. A candidate genetic risk factor for vascular diseases: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
8 Selhub J, Jaques PF, Rosenberg IH, Rogers G, Bowman BA, Gunter EW, Wrigth JD, Johnson CL. Serum total homocysteine concentration in the third national and nutrition examination survey (1991-1994): population references ranges and contribution of vitamin status to high serum concentration. Ann Intern Med 1999; 131: 331-9.
9 Gudnason V, Stansbie D, Scott J, Bowron A, Nicaud V, Humphries S. C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS group. Atherosclerosis 1998; 136: 347-54.
10 Diez-Ewald M, Torres Guerra E, Leets I, Layrisse M, Vizcaíno G, Arteaga-Vizcaíno M. Anemia en poblaciones indígenas del Occidente de Venezuela. Invest Clin 1999; 40: 191-202.