The Impact of the Kozak Sequence Polymorphism of the Glycoprotein Ibα Gene on the Risk and Extent of Coronary Heart Disease

Thromb Haemost 2002; 87(02): 345-346
DOI: 10.1055/s-0037-1612999

Letters to the Editor

Schattauer GmbH

Sentot Santoso

¹Institut für Klinische Immunologic und Transfusionsmedizin

,

Peter Zimmermann

²Institut für Klinische Chemie und Pathobiochemie, Justus-Liebig-Universität Gießen, Germany

,

Ulrich J. H. Sachs

¹Institut für Klinische Immunologic und Transfusionsmedizin

,

Andreas Gardemann

²Institut für Klinische Chemie und Pathobiochemie, Justus-Liebig-Universität Gießen, Germany

References
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2 Afshar-Khargan V, Li CQ, Khoshnevis-Asl M, Lopez JA. Kozak sequence polymorphism of the Glycoprotein (GP) Ibα gene is a major determinant of the plasma membrane levels of the platelet GPIb-IX-V complex. Blood 1999; 94: 186-91.
3 Corral J, Lozano ML, Gonzalez-Conejero R. et al. A common polymorphism flanking the ATG initiator codon of GPIbα does not affect expression and is not a major risk factor for arterial thrombosis. Thromb Haemost 2000; 83: 23-8.
4 Gardemann A, Mages P, Katz N, Tillmanns H, Haberbosch W. The p22 phox A₆₄₀G gene polymorphism but not the C₂₄₂T gene variation is associated with coronary heart disease in younger individuals. Atherosclerosis 1999; 145: 315-23.
5 Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983; 51: 606.
6 Croft SA, Hampton KK, Daly ME, Steeds RP, Channer KS, Samani NJ. Kozak sequence polymorphism in the platelet GPIbα gene is not associated with the risk of myocardial infarction. Blood 2000; 95: 2183.
7 Frank MB, Reiner AP, Schwartz SM. et al. The Kozak sequence polymorphism of platelet glycoprotein Ibα and risk of nonfatal myocardial infarction and nonfatal stroke in young women. Blood 2001; 97: 875-9.