Factor V Leiden and Prothrombin Gene Mutations in Femoral Head Osteonecrosis

Charalampos G. Zalavras; George Vartholomatos; Eleni Dokou; Konstantinos N. Malizos

doi:10.1055/s-0037-1613138

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2002; 87(06): 1079-1080
DOI: 10.1055/s-0037-1613138

Letters to the Editor

Schattauer GmbH

Factor V Leiden and Prothrombin Gene Mutations in Femoral Head Osteonecrosis

Charalampos G. Zalavras

¹Department of Orthopaedic Surgery, LAC + USC Medical Center, University of Southern California, Los Angeles, USA

,

George Vartholomatos

²Haematology Laboratory - Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece

,

Eleni Dokou

²Haematology Laboratory - Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece

,

Konstantinos N. Malizos

³Department of Orthopaedic Surgery, University of Thessalia, Larissa, Greece

References
1 Jones Jr JP. Risk factors potentially activating intravascular coagulation and causing nontraumatic osteonecrosis. In: Osteonecrosis. Etiology, diagnosis and treatment. Urbaniac JR, Jones Jr JP. eds. Rosemont: American Academy of Orthopaedic Surgeons; 1997: 89-96.
2 Zoller B, Garcia de Frutos P, Hillarp A, Dahlback B. Thrombophilia as a multigenic disease. Haematologica 1999; 84: 59-70.
3 Korompilias A, Ortel T, Gilkeson G, Coogan PG, Gunneson EE, Urbaniak JR. Hypercoagulability and osteonecrosis. In: Osteonecrosis. Etiology, diagnosis and treatment. Urbaniac JR, Jones Jr JP. eds. Rosemont: American Academy of Orthopaedic Surgeons; 1997: 111-6.
4 Glueck CJ, Fontaine RN, Gruppo R. et al. The plasminogen activator inhibitor! gene, hypofibrinolysis and osteonecrosis. Clin Orthop 1999; 366: 133-46.
5 Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P. Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop 2001; 386: 19-33.
6 De Stefano V, Chiusolo P, Paciaroni K, Leone G. Epidemiology of factor V Leiden: clinical implications. Semin Thromb Hemost 1998; 24: 367-79.
7 Zoller B, Svensson PJ, He X, Dahlback B. Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest 1994; 94: 2521-4.
8 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’ -untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
9 Glueck CJ, Freiberg R, Tracy T, Tracy T, Stroop D, Wang P. Thrombophilia and hypofibrinolysis. Pathophysiologies of osteonecrosis. Clin Orthop 1997; 334: 43-56.
10 Zalavras C, Dailiana Z, Elisaf M, Bairaktari E, Vlachogiannopoulos P, Ka-tsaraki A, Malizos KN. Potential aetiological factors concerning the development of osteonecrosis of the femoral head. Eur J Clin Invest 2000; 30: 215-21.
11 de Visser MC, Rosendaal FR, Bertina RM. A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis. Blood 1999; 93: 1271-6.
12 Coogan P, Urbaniac JR. Multicenter experience with free vascularized fibular grafts for osteonecrosis of the femoral head. In: Osteonecrosis. Etiology, diagnosis and treatment. Urbaniac JR, Jones Jr JP. eds. Rosemont: American Academy of Orthopaedic Surgeons; 1997: 327-46.
13 Soucacos PN, Beris AE, Malizos KN, Korompilias A, Zalavras H, Dailiana Z. Treatment of avascular necrosis of the femoral head with vascularized fibular transplant. Clin Orthop 2001; 386: 120-30.