Drotrecogin alfa (activated) prolongs half-life time of messenger RNA encoding for Interleukin-8 and Monocyte chemoattractant protein-1

Martina Brueckmann; Siegfried Lang; Martin Borggrefe; Guenter Huhle; Karl Konstantin Haase

doi:10.1055/s-0037-1613430

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 90(06): 1223-1226
DOI: 10.1055/s-0037-1613430

Letters to the Editor

Schattauer GmbH

Drotrecogin alfa (activated) prolongs half-life time of messenger RNA encoding for Interleukin-8 and Monocyte chemoattractant protein-1

Martina Brueckmann

,

Siegfried Lang

,

Martin Borggrefe

,

Guenter Huhle^*

,

Karl Konstantin Haase

Abstract

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References

References
1 Esmon CT, Taylor FB. Snow RT Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C. Thromb Haemost 1991; 66: 160-5.
2 Esmon CT. The protein C anticoagulant pathway. Arterioscler Thromb 1992; 12: 135-45.
3 Joyce DE, Gelbert L, Ciaccia A. et al. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276: 11199-203.
4 Hooper WC, Phillips DJ, Renshaw MA. et al. The up-regulation of IL-6 and IL-8 in human endothelial cells by activated protein C. J Immunol 1998; 161: 2567-73.
5 Hooper WC, Phillips DJ, Renshaw MA. Activated protein C induction of MCP-1 in human endothelial cells - a possible role for endothelial cell nitric oxide synthase. Thrombosis Research 2001; 103: 209-19.
2210-1 Brueckmann M, Marx A, Weiler HM. et al. Stabilization of Monocyte Chemoattractant Protein-1-mRNA by Activated Protein C. Thromb Haemost 2003; 89: 149-60.
6 Rollins BJ. Monocyte chemoattractant pro-tein-1: a potent regulator of monocyte recruitment in inflammatory disease. Mol Med Today 1996; 2: 198-204.
7 Carr MW, Roth SJ, Luther E. et al. Monocyte chemoattractant protein-1 acts as aT-lympho-cyte chemoattractant. Proc Natl Acad Sci USA 1994; 91: 3652-6.
8 Weber KSC, Nelson PJ, Groene H-J. et al. Expression of CCR2 by endothelial cells - implications for MCP-1 mediated wound injury repair and in vivo inflammatory activation of endothelium. Arterioscler Thromb Vase Biol 1999; 19: 2085-93.
9 Jaffe EA, Nachman RL, Becker CG. et al. Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria. J Clin Invest 1973; 52: 2745-56.
10 Greenberg ME, Bender TP. Identification of newly transcribed RNA - nuclear runoff transcription in mammalian cells. In: Current Protocols in Molecular Biology. Wiley & Sons, Inc; New York: 1997: 4.10.1-4.10.11.
11 Sambrock J, Russell DW. Molecular Cloning -a Laboratory Manual - 3rd edition. New York: Cold Spring Harbor Laboratory Press; 2001
12 Tebo J, Der S, Frevel M. et al. Heterogeneity in control of mRNA stability by AU-rich elements. J Biol Chem 2003; 278 (14) 12085-93.
13 Fan XC, Steitz JA. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mR-NAs. The EMBO J 1998; 17: 3448-60.
14 Winzen R, Kracht M, Ritter B. et al. The p38 MAP kinase pathway signals for cytokine-in-duced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. The EMBO J 1999; 18: 4969-80.
15 Yuksel M, Okajima K, Uchiba M. et al. Activated protein C inhibits lipopolysaccha-ride-induced tumor-necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. Thromb Haemost 2002; 88: 267-73.
16 Sachs A. The role of poly(A) in the translation and stability of mRNA. Curr Opin Cell Biol 1990; 2: 1092-8.
17 White B, Schmidt M, Murphy C. et al. Activated protein C inhibits lipopolysaccharide-in-duced nuclear translocation of nuclear factor KB (NF-KB) and tumour necrosis factor α (TNF-α) production in the THP-1 monocytic cell line. Br J Haematol 2000; 110: 130-4.