Download PDF
Thromb Haemost 2000; 83(06): 967-968
DOI: 10.1055/s-0037-1613954
Letters to the Editor
Schattauer GmbH

A New Dilution for the Modified APTT-based Assay for Activated Protein C Resistance: Improvement of the Reliability in Patients with a Lupus Anticoagulant

Norbert Benattar
1   Biogenic S. A., Maurin Montpellier, France
,
Jean-François Schved
2   Laboratoire d’Hématologie, Hôpital Saint-Eloi, Montpellier, France
,
Christine Biron-Andréani
2   Laboratoire d’Hématologie, Hôpital Saint-Eloi, Montpellier, France
› Author Affiliations
Further Information

Publication History

Received 24 November 1999

Accepted after revision 14 February 2000

Publication Date:
14 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
    CrossrefPubMedGoogle Scholar
  • 2 Trossaërt M, Conard J, Horrellou MH, Samama MM, Ireland H, Bayston TA, Lane D. Modified APC resistance in patients on oral anticoagulants. Lancet 1994; 344: 1709.
    PubMedGoogle Scholar
  • 3 Galli M, Duca F, Ruggeri L, Finazzi G, Negri B. Congenital resistance to activated protein C in patients with lupus anticoagulants: evaluation of two functional assays. Thromb Haemost 1998; 80: 246-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Le DT, Donnely KJ, Wu N, Sevilla BK, Rapaport SI. Reliability of a modified tissue factor-dependent factor V assay to detect activated protein C-resistant factor Va using a calcium-containing thromboplastin. Thromb Haemost 1997; 77: 481-5.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Martorell JR, Munoz-Castillo A, Gill JL. False positive activated protein C resistance due to anti-phospholipid antibodies is correct by platelet extract. Thromb Haemost 1995; 74: 794-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Villa P, Aznar J, Jorquera JI, Casana P. Laboratory diagnosis of APCresistance in patients with lupus anticoagulant. Thromb Haemost 1995; 74: 1606-7.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Biron C, Lamarti H, Schved JF, Jeanjean P, Masmejean C, Claustres M, Aguilar-Martinez P. Diagnosis strategies in activated protein C resistance: is genotyping still necessary?. Clin Lab Haem 1997; 19: 67-71.
    CrossrefPubMedGoogle Scholar
  • 8 Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on lupus anticoagulant/antiphospholipid antibody of the Scientific and Standardisation Committee of the ISTH. Thromb Haemost 1995; 74: 1185-90.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 De Ronde H, Bertina RM. Careful selection of sample dilution and factor-Vdeficient plasma makes the modified protein C resistance test highly specific for the factor V Leiden mutation. Blood Coag Fibrinol 1999; 10: 7-17.
    CrossrefPubMedGoogle Scholar