Download PDF
Thromb Haemost 2000; 84(05): 922-923
DOI: 10.1055/s-0037-1614142
Letters to the Editor
Schattauer GmbH

Platelets Abolish the Profibrinolytic Effect of Activated Protein C

Mario Colucci
1   From the Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy
,
Bianca Maria Binetti
1   From the Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy
,
Nicola Semeraro
1   From the Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy
› Author Affiliations
Further Information

Publication History

Received 12 April 2000

Accepted after revision 06 June 2000

Publication Date:
13 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Esmon CT. Regulation of blood coagulation. Biochim Biophys Acta 2000; 1477: 349-60.
    CrossrefPubMedGoogle Scholar
  • 2 De Fouw N, Haverkate F, Bertina RM. Protein C and fibrinolysis: a link between coagulation and fibrinolysis. Adv Exp Med Biol 1990; 281: 235-43.
    PubMedGoogle Scholar
  • 3 Bajzar L, Nesheim ME, Tracy PB. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 1996; 88: 2093-100.
    PubMedGoogle Scholar
  • 4 Sakharov DV, Plow EF, Rijken DC. On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B. J Biol Chem 1997; 272: 14477-82.
    CrossrefPubMedGoogle Scholar
  • 5 Bertina RM. Molecular risk factors for thrombosis. Thromb Haemost 1999; 82: 601-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Taube J, Mc NWilliam, Luddington R, Byrne CD, Baglin T. Activated protein C resistance: effect of platelets, platelet-derived microparticles, and atherogenic lipoproteins. Blood 1999; 93: 3792-7.
    PubMedGoogle Scholar
  • 7 Camire RM, Kalafatis M, Simioni P, Girolami A, Tracy PB. Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C. Blood 1998; 91: 2818-29.
    CrossrefPubMedGoogle Scholar
  • 8 Minnema MC, Friederich PW, Levi M, von dem Borne PA, Mosnier LO, Meijers JCM, Biemond BJ, Hack CE, Bouma BN, ten Cate H. Enhancement of rabbit jugular vein thrombosis by neutralization of factor XI. J Clin Invest 1998; 101: 10-4.
    CrossrefPubMedGoogle Scholar
  • 9 Gresele P, Momi S, Berrettini M, Nenci GG, Schwarz HP, Semeraro N, Colucci M. Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein C reduces intravascular fibrin accumulation through the inhibition of additional thrombin generation. J Clin Invest 1998; 101: 667-76.
    CrossrefPubMedGoogle Scholar