Factor II gene (prothrombin G20210A) mutation and neonatal cerebrovenous thrombosis

Renate Swarte; Inge Appel; Maarten Lequin; Christine van Mol; Paul Govaert

doi:10.1055/s-0037-1614194

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(04): 719-721
DOI: 10.1055/s-0037-1614194

Theme Issue Case Report

Schattauer GmbH

Factor II gene (prothrombin G20210A) mutation and neonatal cerebrovenous thrombosis

Renate Swarte

¹Augustinus Hospital, Antwerpen, Belgium Erasmus Medical Center, Sophia Children’s Hospital, GJ Rotterdam,The Netherlands

,

Inge Appel

¹Augustinus Hospital, Antwerpen, Belgium Erasmus Medical Center, Sophia Children’s Hospital, GJ Rotterdam,The Netherlands

,

Maarten Lequin

¹Augustinus Hospital, Antwerpen, Belgium Erasmus Medical Center, Sophia Children’s Hospital, GJ Rotterdam,The Netherlands

,

Christine van Mol

¹Augustinus Hospital, Antwerpen, Belgium Erasmus Medical Center, Sophia Children’s Hospital, GJ Rotterdam,The Netherlands

,

Paul Govaert

¹Augustinus Hospital, Antwerpen, Belgium Erasmus Medical Center, Sophia Children’s Hospital, GJ Rotterdam,The Netherlands

› Author Affiliations

Abstract

Full Text

References

References
1 deVeber G. Stroke and the child’s brain: an overview of epidemiology, syndromes and risk factors. Curr Opin Neurol 2002; 15: 133-8.
2 Lynch JK, Hirtz DG, deVeber G. et al. Report of the national institute of neurological disorders and stroke workshop on perinatal and childhood stroke. Pediatrics 2002; 109: 116-23.
3 Connor SE, Jarosz JH. Magnetic resonance imaging of cerebral venous sinus thrombosis. Clin Radiol 2002; 57: 449-61.
4 Hanigan WC, Tracy PT, Tadros WS. et al. Neonatal cerebral venous thrombosis. Pediatr Neurosci 1988; 14: 177-83.
5 Aronis S, Bouza H, Pergantou H. et al. Prothrombotic factors in neonates with cerebral thrombosis and intraventricular hemorrhage. Acta Paediatr Suppl 2002; 438: 87-91.
6 Carvalho KS, Bodensteiner JB, Connolly PJ. et al. Cerebral venous thrombosis in children. J Child Neurol 2001; 16: 574-80.
7 Junker R, Koch HG, Auberger K. et al. Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia. Arterioscler Thromb Vasc Biol 1999; 19: 2568-72.
8 Poort SR, Rosendaal FR, Reitsma PM. et al. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
9 van Ommen CH, Heijboer H, van den Dool EJ. et al. Pediatric venous thromboembolic disease in one single center: congenital prothrombotic disorders and the clinical outcome. J Thromb Haemost 2003; 01: 2516-22.
10 Delsing BJP, Catsman-Berrevoets CE, Appel IM. Early prognostic indicators of outcome in ischemic childhood stroke. Pediatr Neurol 2001; 24: 283-9.
11 Schobess R, Junker R, Auberger K. et al. Factor V G1691A and prothrombin G20210A in childhood spontaneous venous thrombosis. Evidence of an age-dependent thrombotic onset in carriers of factor V G1691A and prothrombin G20210A mutation. Eur J Pediatr 1999; 158: S105-8.
12 von Ahsen N, Lewczuk P, Schütz E. et al. Prothrombin activity and concentrations in healthy subjects with and without the prothrombin G20210A mutation. Thromb Res 2000; 99: 549-56.
13 van Ommen CH, Heijboer H, Buller H. et al. Venous thromboembolism in childhood: A prospective two-year registry in The Netherlands. J Pediatr 2001; 139: 676-81.
14 Govaert P, Achten E, van Haesebrouck P. et al. Deep cerebral venous thrombosis in thalamoventricular hemorrhage of the term newborn. Pediatr Radiol 1992; 22: 123-7.
15 Voorhies TM, Lipper EG, Lee BC. et al. Occlusive vascular disease in asphyxiated newborn infants. J Pediatr 1984; 105: 92-6.
16 Edstrom CS, Christensen RD. Evaluation and treatment of thrombosis in the neonatal intensive care unit. Clin Perinatol 2000; 27: 623-41.
17 Friese S, Müller-Hansen I, Schöning M. et al. Isolated internal cerebral venous thrombosis in a neonate with increased lipoprotein (a) level: diagnostic and therapeutic considerations. Neuropediatrics 2003; 34: 36-9.
18 Nowak-Göttle U, Debus O, Findeisen M. et al. Lipoprotein (a): its role in childhood thromboembolism. Pediatrics 1997; 99: E11.
19 de Veber G, Chan AC, Monagle P. et al. Anticoagulation therapy in pediatric patients with sinovenous thrombosis. Arch Neurol 1988; 55: 1533-7.
20 Ehlers H, Courville CB. Thrombosis of internal cerebral veins in infancy and childhood. J Pediatr 1936; 08: 600-23.