D-dimer Strategy in Thrombosis Exclusion

G. Freyburger; H. Trillaud; S. Labrouche; P. Gauthier; S. Javorschi; P. Bernard; N. Grenier

doi:10.1055/s-0037-1614214

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 79(01): 32-37
DOI: 10.1055/s-0037-1614214

Review Article

Schattauer GmbH

D-dimer Strategy in Thrombosis Exclusion

A Gold Standard Study in 100 Patients Suspected of Deep Venous Thrombosis or Pulmonary Embolism: 8 DD Methods Compared

G. Freyburger

¹From the Laboratoire d’Hématologie, Bordeaux, France

,

H. Trillaud

²From the Service de Radiologie, Hôpital Pellegrin, Université BxII, Bordeaux, France

,

S. Labrouche

¹From the Laboratoire d’Hématologie, Bordeaux, France

,

P. Gauthier

²From the Service de Radiologie, Hôpital Pellegrin, Université BxII, Bordeaux, France

,

S. Javorschi

¹From the Laboratoire d’Hématologie, Bordeaux, France

,

P. Bernard

¹From the Laboratoire d’Hématologie, Bordeaux, France

,

N. Grenier

²From the Service de Radiologie, Hôpital Pellegrin, Université BxII, Bordeaux, France

› Author Affiliations

Abstract

Summary

DD are now recognized as a valuable tool to screen patients suspected of deep venous thrombosis or pulmonary embolism before carrying out a gold standard radiologic examination. The newest methods available claim to be able to ascertain the absence of thrombosis, but they have yet to prove their efficiency. We compared the performances of 3 reference ELISA methods (D-DI Asserachrom™ Stago, D-dimer Enzygnost™ Behring and Dimertest GOLD EIA™ Agen), 5 recent rapid methods (VIDAS D-Dimer™ bioMérieux, Instant IA™ Stago, Simplired™ Agen, Nycocard D-dimer™ Nycomed and Accuclot D-Dimer™ Sigma Diagnostics) and two routine latex methods (Dimertest™ American Diagnostica and FDP-Slidex™ bioMérieux) in 100 patients. One of the rapid quantitative methods was demonstrated to have a level of efficiency comparable to that of ELISA methods. Finally, the cost and efficiency of different strategies were evaluated, the association of a routine latex method with the VIDAS D-Dimer™ bioMérieux being proven to be the most efficient.

Full Text

References

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