Clustering of Integrin αIIb-β3Differently Regulates Tyrosine Phosphorylation of pp72syk, PLCγ2 and pp125FAKin Concanavalin A-stimulated Platelets

Mauro Torti; Enrico Tolnai Festetics; Alessandra Bertoni; Fabiola Sinigaglia; Cesare Balduini

doi:10.1055/s-0037-1614429

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1999; 81(01): 124-130
DOI: 10.1055/s-0037-1614429

Review Article

Schattauer GmbH

Clustering of Integrin α_IIb-β₃Differently Regulates Tyrosine Phosphorylation of pp72^syk, PLCγ2 and pp125^FAKin Concanavalin A-stimulated Platelets

Mauro Torti

,

Enrico Tolnai Festetics

,

Alessandra Bertoni

,

Fabiola Sinigaglia

¹ From the Department of Biochemistry, University of Pavia, Pavia, Italy, Institute of Biological Chemistry, University of Genoa, Genoa, Italy

,

Cesare Balduini

› Institutsangaben

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References
1 Jackson SP, Schoenwaelder SM, Yuan Y, Salem HH, Cooray P. Non-receptor protein tyrosine kinases and phosphatases in human platelets. Thromb Haemost 1996; 76: 640-50.
2 Torti M, Lapetina EG. Role of rap1B and the p21^ras GTPase activating protein in the regulation of phospholipase Cγ1 in human platelets. Proc Natl Acad Sci USA 1992; 89: 7796-800.
3 Vostal JG, Shulman NR. Vinculin is a major platelet protein that undergoes Ca²⁺-dependent tyrosine phosphorylation. Biochem J 1993; 294: 675-80.
4 Taniguchi T, Kitagawa H, Yasue S, Yanagi S, Sakai K, Asahi M, Otha S, Takeuchi F, Nakamura S, Yamamura H. Protein-tyrosine kinase p72^syk is activated by thrombin and is negatively regulated through Ca²⁺ mobilization in platelets. J Biol Chem 1993; 268: 2277-9.
5 Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp72^syk by platelet agonists and the integrin α_IIb-β₃ . J Biol Chem 1994; 269: 28859-64.
6 Li RY, Gaits F, Ragab A, Ragab-Thomas JMF, Chap H. Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. EMBO J 1995; 14: 2519-26.
7 Ferrell Jr JE, Martin GS. Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Proc Natl Acad Sci USA 1989; 86: 2234-8.
8 Golden A, Brugge JS, Shattil SJ. Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J Cell Biol 1990; 111: 3117-27.
9 Lipfert L, Haimovich B, Schaller MB, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125^FAK in platelets. J Cell Biol 1992; 119: 905-12.
10 Haimovich B, Lipfert L, Brugge JS, Shattil SJ. Tyrosine phosphorylation and cytoskeletal reorganisation in platelets are triggered by interaction of integrin receptors with their immobilised ligands. J Biol Chem 1993; 268: 15868-77.
11 Huang M, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SJ. Adhesive ligand binding to integrin α_IIb-β₃ stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125^FAK . J Cell Biol 1993; 122: 473-83.
12 Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ. Regulation of the pp72^syk protein tyrosine kinase by platelet integrin α_IIb-β₃ . EMBO J 1997; 16: 6414-25.
13 Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125^FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem 1994; 269: 14738-45.
14 Isenberg WM, McEver RP, Phillips DR, Schuman MA, Bainton DF. The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering. J Cell Biol 1987; 104: 1655-63.
15 Lawler J. The structural and functional properties of thrombospondin. Blood 1986; 67: 1197-209.
16 Phillips DR, Jennings LK, Edwards HH. Identification of membrane proteins mediating the interaction of human platelets. J Cell Biol 1980; 86: 77-86.
17 Newman PJ, Hillery CA, Albrecht R, Parise LV, Berndt MC, Mazurov AV, Dunlop L C, Zhang J, Rittenhouse SE. Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution. J Cell Biol 1992; 119: 239-46.
18 Torti M, Balduini C, Ramaschi G, Sinigaglia F. Stimulation of human platelets with Concanavalin A involves phospholipase C activation. Cell Biochem Funct 1992; 10: 53-9.
19 Wheeler ME, Gerrard JM, Carrol RC. Reciprocal transmembranous receptor-cytoskeleton interaction in Concanavalin A-activated platelets. J Cell Biol 1985; 101: 993-1000.
20 Fitzgerald LA, Leung B, Phillips DR. A method for purifying platelet membrane glycoprotein IIb-IIIa complex. Anal Biochem 1985; 151: 169-77.
21 Kakaiya RM, Kiroly TL, Cable RG. Concanavalin A induces patching/ capping of the platelet membrane glycoprotein IIb-IIIa complex. Thromb Haemost 1988; 59: 281-3.
22 Torti M, Ramaschi G, Sinigaglia F, Balduini C. Dual mechanism of protein tyrosine phosphorylation in Concanavalin A-stimulated platelets. J Cell Biochem 1995; 57: 30-8.
23 Keeley PJ, Parise LV. The α₂β₁ integrin is a necessary co-receptor for collagen-induced activation of Syk and the subsequent phosphorylation of phospholipase Cγ2 in platelets. J Biol Chem 1996; 272: 26668-76.
24 Tate BF, Rittenhouse SE. Thrombin activation of human platelets causes tyrosine phosphorylation of PLC-γ2. Biochim Biophys Acta 1993; 1178: 281-5.
25 Daniel JL, Dangelmaier C, Smith JB. Evidence for a role for tyrosine phosphorylation of phospholipase Cγ2 in collagen-induced platelet cytosolic calcium mobilization. Biochem J 1994; 302: 617-22.
26 Moroi M, Jung SM. Selective staining of human platelet glycoproteins using nitrocellulose transfer of electrophoresed proteins and peroxidase-conjugated lectins. Biochim Biophys Acta 1984; 798: 295-301.
27 Gunther GR, Wang JL, Yahara I, Cunningham BA, Edelman GM. Concanavalin A derivatives with altered biological activities. Proc Natl Acad Sci USA 1973; 70: 1012-6.
28 Rhee SG. Inositol phospholipid-specific phospholipase C: interaction of the γ1 isoform with tyrosine kinase. Trends Biochem Sci 1991; 16: 297-301.
29 Asselin J, Gibbins JM, Achison M, Lee YH, Morton LF, Farndale RW, Barnes MJ, Watson SP. A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase Cγ2 in platelets independent of integrin α₂β₁ . Blood 1997; 89: 1235-42.
30 Torti M, Ramaschi G, Montsarrat N, Sinigaglia F, Balduini C, Plantavid M, Breton M, Chap H, Mauco G. Evidence for a glycoprotein IIb-IIIa- and aggregation-independent mechanism of phosphatidylinositol 3’,4’-bisphosphate synthesis in human platelets. J Biol Chem 1995; 270: 13179-85.
31 Indig FE, Diaz-Gonzales F, Ginsberg MH. Analysis of tetraspanin CD9-in-tegrin α_IIb-β₃ (GP IIb-IIIa) complex in platelet membranes and transfected cells. Biochem J 1997; 327: 291-8.
32 Chacko GW, Duchemin A, Coggeshall KM, Osborne JM, Brandt JT, Anderson CL. Clustering of the platelet Fcγ receptor induces noncovalent association with the tyrosine kinase p72^syk . J Biol Chem 1994; 269: 32435-40.
33 Ichinohe T, Takayama H, Yasuharu E, Arai M, Yamamoto N, Takahashi H, Okuma M. Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI. J Biol Chem 1997; 272: 63-8.