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Thromb Haemost 1999; 81(05): 844-845
DOI: 10.1055/s-0037-1614579
Letters to the Editor
Schattauer GmbH

Placental Genotyping of the Factor V Leiden, Prothrombin 20210A and the Methylenetetrahydrofolate Reductase (MTHFR) C677T Alleles in IUGR Pregnancies

Jeffrey D. Wisotzkey
1   From the Departments of Research and Obstetrics and Gynecology
,
Philip Bayliss
2   Division of Maternal Fetal Medicine
3   York Hospital, York, PA, USA
,
Elizabeth Rutherford
2   Division of Maternal Fetal Medicine
,
Ted Bell
1   From the Departments of Research and Obstetrics and Gynecology
› Author Affiliations
Further Information

Publication History

Received 03 July 1998

Accepted 22 January 1999

Publication Date:
09 December 2017 (online)

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  • References

  • 1 Grandone E, Margaglione M, Colaizzo D, d"Addedda M, Cappucci G, Vecchione G, Scianname N, Pavone G, DiMinno G. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses.. Thromb Haemost 1997; 77: 822-4.
    Thieme ConnectPubMedSearch in Google Scholar
  • 2 Dizon-Townson DS, Meline L, Nelson LM, Varner M, Ward K. Fetal carriers of the factor V Leiden mutation are prone to miscarrage and placental infarction.. Am J Obstet Gynecol 1997; 177: 402-5.
    CrossrefPubMedSearch in Google Scholar
  • 3 Grandone E, Margaglione M, Colaizzo D, Cappucci G, Paladini D, Martinelli P, Montanaro S, Pavone G, Di Minno G. Factor V Leiden, C>T MTHFR polymorphism and genetic susceptability to preeclampsia.. Thromb Haemost 1997; 77: 1052-4.
    Thieme ConnectPubMedSearch in Google Scholar
  • 4 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3" untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thromboembolism.. Blood 1998; 88: 3698-703.
    PubMedSearch in Google Scholar
  • 5 Arruda VR, Annichino-Bizzacchi JM, Goncalves MS, Costa FF. Prevalence of the prothrombin gene variant (nt20210A) in venous thrombosis and arterial disease.. Thromb Haemost 1998; 78: 1430-3.
    Thieme ConnectPubMedSearch in Google Scholar
  • 6 Salafia CM, Minior VK, Pezzullo JC, Popek EJ, Rosenkrantz TS, Vintzileos AM. Intrauterine growth restriction in infants of less than thirty two week"s gestation: associated placental pathologic features.. Am J Obstet Gynecol 1995; 173: 1049-57.
    CrossrefPubMedSearch in Google Scholar
  • 7 Dekker GA, de Vries JIP, Doelitzsch PM, Huijgens PC, von Blomberg BME, Jakobs C, van Geijn HP. Underlying disorders associated with severe early-onset preeclampsia.. Am J Obstet Gynecol 1995; 173: 1042-8.
    CrossrefPubMedSearch in Google Scholar
  • 8 Salafia CM, Pezzullo JC, Lopez-Zeno JA, Simmens S, Minior VK, Vintzileos AM. Placental pathologic features of preterm preeclampsia.. Am J Obstet Gynecol 1995; 173: 1097-105.
    CrossrefPubMedSearch in Google Scholar
  • 9 Hirsch DR, Mikkola KM, Marks PW, Fox EA, Dorfman DM, Ewenstein BM, Goldhaber SZ. Pulmonary embolism and deep venous thrombosis during pregnancy or oral contraceptive use: prevalence of factor V Leiden.. Am Heart J 1996; 131: 1145-8.
    CrossrefPubMedSearch in Google Scholar
  • 10 Syverson CJ, Chavkin W, Atrash HK, Rochat RW, Sharp ES, King EG. Pregnancy related mortality in New York City, 1980 to 1984: causes of death and associated risk factors.. Am J Obstet Gynecol 1991; 164: 603-8.
    CrossrefPubMedSearch in Google Scholar
  • 11 Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy.. Thromb Haemost 1984; 52: 176-82.
    Thieme ConnectPubMedSearch in Google Scholar
  • 12 Reverdiau-Moalic P, Delahousse B, Body G, Bardos P, Leroy J, Gruel Y. Evolution of blood coagulation activators and inhibitors in the healthy human fetus.. Blood 1996; 88: 900-6.
    CrossrefPubMedSearch in Google Scholar
  • 13 Wilcox GR, Trudinger BJ, Exner T. The coagulation system in placental insufficiency: a study in the fetal circulation. Br J Obstet Gynaecol 1993; 100:: 1101-6.
    CrossrefPubMedSearch in Google Scholar
  • 14 Hadlock FP, Harrist RB, Sharman RS. Estimating fetal weight with the use of head, body, and femur measurements: A prospective study.. Am J Obstet Gynecol 1985; 151: 333-7.
    CrossrefPubMedSearch in Google Scholar
  • 15 Liu X, Nelson D, Grant C, Morthland V, Goodnight S, Press R. Molecular detection of a common mutation in coagulation factor V causing thrombosis via hereditary resistance to activated protein C.. Diagn Mol Pathol 1995; 4: 191-7.
    CrossrefPubMedSearch in Google Scholar
  • 16 Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Mathews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahyrdofolate reductase.. Nat Genet 1995; 10: 111-13.
    CrossrefPubMedSearch in Google Scholar
  • 17 Burick A, Wisotzkey JD, Najarian MP, Monk JS, Rhoads JE. The role of preoperative factor V Leiden screening in different geographic populations.. Am Surg 1997; 63: 547-50.
    PubMedSearch in Google Scholar