Prothrombin Gene Mutation (G20210A) in Healthy Centenarians

Elisabetta Sacchi; Francesca Duca; Claudio Franceschi; Daniela Mari

doi:10.1055/s-0037-1614613

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 81(06): 990-991
DOI: 10.1055/s-0037-1614613

Letters to the Editor

Schattauer GmbH

Prothrombin Gene Mutation (G20210A) in Healthy Centenarians

Elisabetta Sacchi

¹From A. Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Fondazione “Luigi Villa”, Centro Studi di Patologia Molecolare Applicata alla Clinica, Milan

,

Francesca Duca

¹From A. Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Fondazione “Luigi Villa”, Centro Studi di Patologia Molecolare Applicata alla Clinica, Milan

,

Claudio Franceschi

²Gerontological Research IRCCA, Ancona

,

Daniela Mari

³Department of Internal Medicine, Milan, Italy

› Author Affiliations

Abstract

Full Text

References

References
1 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
2 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
3 Rosendaal FR, Doggen CJM, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.
4 Mari D, Mannucci PM, Duca F, Bertolini S, Franceschi C. Mutant factor V (Arg506Gln) in healthy centenarians. Lancet 1996; 347: 1044 (letter)
5 Hézard N, Cornillet-Lefebvre P, Gillot L, Potron G, Nguyen P. Multiplex ASA PCR for a simultaneous determination of factor V Leiden gene, G-A 20210 prothrombin gene and C-T 677 MTHFR gene mutations. Thromb Haemost 1998; 79: 1054 (letter)
6 Faure-Delanef L, Quéré I, Zouali H, Cohen D. Human longevity and R506Q factor V gene mutation. Thromb Haemost 1997; 78: 1160.
7 Kristensen SR, Andersen-Ranberg K, Bathum L, Jeune B.. Factor V Leiden and venous thrombosis in Danish centenarians. Thromb Haemost 1998; 80:: 860-1.