Differences in Levels of Soluble E-selectin and VCAM-1 in Malignant versus non Malignant Mediterranean Spotted Fever

Françoise Dignat-George; Hervé Tissot-Dupont; Georges-Emile Grau; Laurence Camoin-Jau; Didier Raoult; José Sampol

doi:10.1055/s-0037-1614887

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(06): 1610-1613
DOI: 10.1055/s-0037-1614887

Rapid Communication

Schattauer GmbH

Differences in Levels of Soluble E-selectin and VCAM-1 in Malignant versus non Malignant Mediterranean Spotted Fever

Françoise Dignat-George

¹From the Laboratoire d’Hématologie, Hôpital de La Conception, Marseille, France

,

Hervé Tissot-Dupont

²Unité des Rickettsies, CNRS UPRES A 6020, Faculté de Médecine, Marseille, France

³Service des Maladies Infectieuses, Hôpital de La Conception, Marseille, France

,

Georges-Emile Grau

¹From the Laboratoire d’Hématologie, Hôpital de La Conception, Marseille, France

²Unité des Rickettsies, CNRS UPRES A 6020, Faculté de Médecine, Marseille, France

,

Laurence Camoin-Jau

¹From the Laboratoire d’Hématologie, Hôpital de La Conception, Marseille, France

,

Didier Raoult

²Unité des Rickettsies, CNRS UPRES A 6020, Faculté de Médecine, Marseille, France

,

José Sampol

¹From the Laboratoire d’Hématologie, Hôpital de La Conception, Marseille, France

› Author Affiliations

Abstract

Summary

In the present study, we investigated the plasma levels of soluble adhesion molecules E-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in 24 patients with Mediterranean spotted fever (MSF), 6 of whom with a malignant form. Measurements were performed on blood samples collected before treatment (T1), then twice during treatment (T2 and T3). Before treatment, MSF patients taken as a whole presented elevated levels of sICAM-1 and sVCAM-1 and normal levels of sE-selectin and sP-selectin compared to healthy controls. We found that sICAM-1 was elevated both in mild and malignant MSF. sE-selectin and sVCAM-1 were elevated only in patients with the malignant form and allowed to discriminate the two clinical subgroups. Their levels decreased after treatment with sE-selectin reaching control values at T2 whereas sVCAM-1 remained higher over the course of the malignant form. In patients with mild MSF, sP-selectin steadily increased after treatment, whereas it did not present any modification at any of the two sampling times in patients with the malignant form. Raised plasma levels of sE-selectin and sVCAM-1 reflect endothelial activation in malignant rickettsial disease and may be sufficiently early markers to influence the therapeutic decision.

Key Words

Soluble adhesive molecules - endothelial cell - Mediterranean spotted fever

Full Text

References

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