Platelet cNOS Activity Is Reduced in Patients with IDDM and NIDDM

Valentino Martina; Guido A. Bruno; Fulvia Trucco; Elena Zumpano; Milena Tagliabue; Cataldo Di Bisceglie; Gianpiero Pescarmona

doi:10.1055/s-0037-1614937

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 79(03): 520-522
DOI: 10.1055/s-0037-1614937

Review Articles

Schattauer GmbH

Platelet cNOS Activity Is Reduced in Patients with IDDM and NIDDM

Valentino Martina

¹Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy

,

Guido A. Bruno

¹Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy

,

Fulvia Trucco

¹Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy

,

Elena Zumpano

¹Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy

,

Milena Tagliabue

¹Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy

,

Cataldo Di Bisceglie

¹Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy

,

Gianpiero Pescarmona

¹Dipartimento di Medicina Interna, Divisione di Endocrinologia, Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Italy

› Author Affiliations

Abstract

Summary

Several studies in vitro and in vivo suggest that the nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to vascular alteration facilitating platelet-vascular wall interaction, adhesion of monocytes to endothelium, vascular smooth muscle proliferation and by decreasing endothelium-dependent vasodilation. In this study we evaluated the activity of the constitutive nitric oxide synthase (cNOS) in platelets of patients with insulin-dependent diabetes mellitus (IDDM) and with non-insulin-dependent diabetes mellitus (NIDDM). When compared to that of normal subjects, cNOS activity is significantly lower in patients with IDDM and with NIDDM (1.57 ± 0.25 vs. 0.66 ± 0.10 fmol/min/10 9 PLTs and 1.57 ± 0.25 vs. 0.67 ± 0.08, respectively; p <0.005). These data demonstrate that the platelet cNOS activity is decreased in diabetes mellitus.

Full Text

References

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