Inhibitory Effect of Argatroban on Thrombin-induced MAP Kinase Activation

A. Hijikata-Okunomiya; Y. Nakaya; A. Takahashi; N. Inoue; T. Taniguchi; Y. Ishikawa

doi:10.1055/s-0037-1615247

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 80(03): 528-529
DOI: 10.1055/s-0037-1615247

Letters to the Editor

Schattauer GmbH

Inhibitory Effect of Argatroban on Thrombin-induced MAP Kinase Activation

A. Hijikata-Okunomiya

¹From Kobe University School of Medicine, Kobe, Japan

,

Y. Nakaya

¹Kobe Research Projects on Thrombosis and Haemostasis, Kobe, Japan

,

A. Takahashi

¹From Kobe University School of Medicine, Kobe, Japan

,

N. Inoue

¹From Kobe University School of Medicine, Kobe, Japan

,

T. Taniguchi

¹From Kobe University School of Medicine, Kobe, Japan

,

Y. Ishikawa

¹From Kobe University School of Medicine, Kobe, Japan

› Author Affiliations

Abstract

Full Text

References

References
1 Okamoto S, Hijikata A, Kikumoto R, Tonomura S, Hara H, Ninomiya K, Maruyama A, Sugano M, Tamao Y. Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its carboxamide portion. Biochem Biophys Res Commun 1981; 101: 440-6.
2 Hijikata-Okunomiya A, Okamoto S. A strategy for a rational approach to designing synthetic selective inhibitors. Semin Thromb Hemost 1992; 18: 135-49.
3 Tanabe T, Mishima Y, Furukawa K, Sakaguchi S, Kamiya K, Shionoya S, Katsumura T, Kusaba A. Clinical results of MD805, antithrombin agent, on chronic arterial occlusion – multi-center cooperative study. J Clin Ther Med 1986; 2: 1645-55.
4 Yonekawa Y, Handa H, Okamoto S, Kamijo Y, Oda Y, Ishikawa J, Tsuda H, Shimizu Y, Satoh M, Yamagami T, Yano I, Horikawa Y, Tsuda E. Treatment of cerebral infarction in the acute stage with synthetic antithrombin MD805: Clinical study among multiple institutions. Arch Jpn Chir 1986; 55: 711-26.
5 Suzuki S, Sakamoto S, Adachi K, Mizutani K, Koide M, Ohga N, Miki T, Matsuo T. Effect of argatroban on thrombus formation during acute coronary occlusion after balloon angioplasty. Thromb Res 1995; 77: 369-73.
6 Molloy CJ, Pawlowski JE, Taylor DS, Turner CE, Weber H, Peluso M, Seiler SM. Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells. J Clin Invest 1996; 97: 1173-83.
7 McNamara CA, Sarembock IJ, Gimple LW, Fenton II JW, Coughlin SR, Owens GK. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 1993; 91: 94-8.
8 Imanishi T, Arita M, Hamada M, Tomobuchi Y, Hano T, Nishio I. Effect of locally administration of argatroban using a hydrogel-coated balloon catheter on intimal thickening induced by balloon injury. Jpn Circ J 1998; 61: 256-62.