Fibrinogen Plasma Levels in an Apparently Healthy General Population – Relation to Environmental and Genetic Determinants

Maurizio Margaglione; Giuseppe Cappucci; Donatella Colaizzo; Leonardo Pirro; Gennaro Vecchione; Elvira Grandone; Giovanni Di Minno

doi:10.1055/s-0037-1615362

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 80(05): 805-810
DOI: 10.1055/s-0037-1615362

Review Article

Schattauer GmbH

Fibrinogen Plasma Levels in an Apparently Healthy General Population – Relation to Environmental and Genetic Determinants

Maurizio Margaglione

¹From the Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

,

Giuseppe Cappucci

¹From the Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

,

Donatella Colaizzo

¹From the Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

,

Leonardo Pirro

¹From the Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

,

Gennaro Vecchione

¹From the Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

,

Elvira Grandone

¹From the Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

,

Giovanni Di Minno

²Istituto di Gerontologia e Geriatria, Università di Palermo, Italy

› Author Affiliations

Abstract

Summary

Elevated fibrinogen levels are an independent risk factor for cardiovascular ischemic disease. We investigated the relationship between cardiovascular ischemic risk factors, the fibrinogen Bβ-chain G/A^-455 polymorphism and plasma fibrinogen levels in 989 apparently healthy subjects. Fibrinogen values were higher in subjects with C reactive protein (C-RP) > 0.33 mg/dl, BMI > 23.9 kg/m², total cholesterol > 4.84 mmol/l, triglycerides >1.02 mmol/l, PAI-1 antigen >12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming >10 cigarettes per day (p <0.01). Men and ethanol drinkers showed lower plasma fibrinogen levels (p <0.01). The multivariate analysis confirmed the independent effect of C-RP, age, BMI, total cholesterol, gender, PAI-1, -455 G/A polymorphism, (p <0.05). BMI, total cholesterol, PAI-1, alcohol and smoking habit raised with the increase of age and differed between sexes. The A^-455 allele increasing effect was significant in women, especially in subjects aged <30 years, and in men aged <43 years. These results indicate that environmental factors contributed to a larger extent to fibrinogen variability, whereas the A^-455 allele was associated with a steeper increase in younger age quartiles.

Full Text

References

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