The Risk of Mortality and the Factor V Leiden Mutation in a Population-based Cohort

Bastiaan T. Heijmans; Rudi G. J. Westendorp; Dick L. Knook; Cornelis Kluft; Eline P. Slagboom

doi:10.1055/s-0037-1615430

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 80(04): 607-609
DOI: 10.1055/s-0037-1615430

Rapid Communication

Schattauer GmbH

The Risk of Mortality and the Factor V Leiden Mutation in a Population-based Cohort

Bastiaan T. Heijmans

¹From the Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands

²From the Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

,

Rudi G. J. Westendorp

²From the Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

³From the Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

,

Dick L. Knook

¹From the Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands

²From the Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

,

Cornelis Kluft

¹From the Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands

,

Eline P. Slagboom

¹From the Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands

› Author Affiliations

Abstract

Summary

The factor V Leiden mutation (conferring resistance to activated protein C) has been implicated in the risk of arterial thrombosis and is a well-established risk factor for venous thrombosis especially in the elderly. We studied whether the disease association of the factor V mutation is reflected in an increased all-cause and cause-specific mortality.

First, the prevalence of the factor V Leiden mutation was determined in a population-based study among subjects aged 85 years and over (4.7%, n = 660) and was found to correspond to the prevalence in young subjects aged 18 to 40 years (5.0%, n = 321). Secondly, we studied the association of factor V Leiden with the risk of all-cause mortality and specific causes of death in the elderly cohort during a 10-year follow-up period. Neither the all-cause mortality risk (RR 1.0; 95% CI, 0.7-1.5), nor the risk of death due to cardiovascular disease (RR 0.9; 95% CI, 0.5-1.7) were increased in elderly subjects heterozygous for factor V Leiden. Our study thus indicates that heterozygosity for factor V Leiden does not affect population mortality.

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References

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