Impact of Apolipoprotein(a) Isoform Size Heterogeneity on the Lysine Binding Function of Lipoprotein(a) in Early Onset Coronary Artery Disease

Josep M. Simó; Jorge Joven; Elisabet Vilella; Montserrat Ribas; Miguel A. Pujana; Indirana M. Sundaram; Jeffrey P. Hammel; Jane L. Hoover-Plow

doi:10.1055/s-0037-1615598

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 85(03): 412-417
DOI: 10.1055/s-0037-1615598

Review Article

Schattauer GmbH

Impact of Apolipoprotein(a) Isoform Size Heterogeneity on the Lysine Binding Function of Lipoprotein(a) in Early Onset Coronary Artery Disease

Josep M. Simó

¹Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan

,

Jorge Joven^*

¹Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan

,

Elisabet Vilella

¹Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan

,

Montserrat Ribas

¹Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan

,

Miguel A. Pujana

²Institut de Recerca Oncològica, Reus, Spain

,

Indirana M. Sundaram

³Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Dept. of Molecular Cardiology, Lerner Research Institute

,

Jeffrey P. Hammel

⁴Dept. of Biostatistics and Epidemiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

,

Jane L. Hoover-Plow

³Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Dept. of Molecular Cardiology, Lerner Research Institute

› Author Affiliations

Abstract

Summary

Elevated plasma Lp(a) is an independent risk factor for cardiovascular disease. Unique to Lp(a) is the apoprotein, apo(a) which can vary from 250 to 800 kDa in molecular weight. Small isoforms are also associated with the risk of cardiovascular disease. The purpose of this study was to examine the association of Lp(a) concentration, apo(a) size, and Lp(a) lysine-binding site(s) (LBS) function in patients with early onset heart disease, and age-matched controls. Mean values of Lp(a) were significantly higher in the patients than for the age-matched group. The smallest molecular weight isoform for each subject had significantly fewer kringles for the patients than the age-matched controls. There was a significant correlation between LBS activity and kringle number in the single-banded phenotypes of the patients, but not the controls. LBS activity was significantly higher in patients with small isoforms (≤18 kringles) compared to controls. The odds ratio for coronary artery disease for high LBS activity and high Lp(a) concentration was 4.4 (p = 0.002) and for high LBS activity and small isoforms was 10.1 (p = 0.002). In the patients, Lp(a) concentration was higher, apo(a) size was smaller, and LBS activity higher in the small isoforms compared to the controls. This study suggests an association of high LBS activity in small isoforms of Lp(a) with disease in humans.

Keywords

Lipoprotein(a) - apo(a) size - lysine binding site function - myocardial infarction

Full Text

References

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