Idiopathic Deep Vein Thrombosis in Siblings with Homozygous Factor V Leiden Mutation

Thromb Haemost 2001; 85(03): 562-563
DOI: 10.1055/s-0037-1615625

Letters to the Editor

Schattauer GmbH

Herwig Köppel

¹Department of Medicine, Division of Angiology, Karl Franzens-University Graz, Austria

,

Wilfried Renner

¹Department of Medicine, Division of Angiology, Karl Franzens-University Graz, Austria

,

Gerald Seinost

¹Department of Medicine, Division of Angiology, Karl Franzens-University Graz, Austria

,

Ernst Pilger

¹Department of Medicine, Division of Angiology, Karl Franzens-University Graz, Austria

References
1 Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High Risk of Thrombosis in Patients Homozygous for Factor V Leiden (Activated Protein C Resistance). Blood Vol 85 No (Suppl. 06) 1995; pp 1504-1508.
2 Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 330: 517-22.
3 Koster T, Rosendaal FR, de Ronde H, Briët E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-6.
4 Greengard JS, Eichinger S, Griffin JH, Bauer KA. Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C due to an Arg-Gln Mutation in the Gene for Factor V. N Engl J Med 1994; 331: 1559-62.
5 Eichinger S, Pabinger I, Stümpflen A, Hirschl M, Bialonczyk Ch, Schneider B, Mannhalter Ch, Minar E, Lechner K, Kyrle PA. The Risk of Recurrent Venous Thromboembolism in Patients with and without Factor V Leiden. Thromb Haemost 1997; 77 (Suppl. 04) 624-8.