Platelet Glycoprotein Receptor IIIa Polymorphism PlA1/PlA2 and Coronary Risk: a Meta-Analysis

Augusto Di Castelnuovo; Giovanni de Gaetano; Maria Benedetta Donati; Licia Iacoviello

doi:10.1055/s-0037-1615644

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 85(04): 626-633
DOI: 10.1055/s-0037-1615644

Review Articles

Schattauer GmbH

Platelet Glycoprotein Receptor IIIa Polymorphism Pl^A1/Pl^A2 and Coronary Risk: a Meta-Analysis

Augusto Di Castelnuovo

¹“Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

,

Giovanni de Gaetano

¹“Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

,

Maria Benedetta Donati

¹“Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

,

Licia Iacoviello

¹“Angela Valenti” Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

› Author Affiliations

Abstract

Summary

Membrane glycoprotein IIb/IIIa plays a major role in platelet function. The gene encoding the glycoprotein IIIa shows a common polymorphism Pl^A1/Pl^A2 that was variably associated with vascular disease. To clarify the role of Pl^A1/Pl^A2 polymorphism in coronary risk, a meta-analysis of published data was conducted. Studies were identified both by MEDLINE searches, and hand searching of journals and abstract books.

A total of 34 studies for coronary artery disease (CAD), and 6 for restenosis after revascularization were identified, for a total of 9,095 cases and 12,508 controls. In CAD, the overall odds ratio for carriers of the Pl^A2 allele was 1.10 (95% CI: 1.03 to 1.18), and it was 1.21 (95% CI: 1.05 to 1.38) in subjects younger than 60. Overall odds ratio was 1.31 (95% CI: 1.10 to 1.56) after revascularization procedures.

The association of Pl^A2 status with overall cardiovascular disease in the general population is significant but weak; higher risk has been identified in less heterogeneous subgroups as in the younger cohorts and in the restenosis subset with stents.

Keywords

Coronary disease - genes - platelet glycoprotein - Pl^A1/Pl^A2 polymorphism - meta-analysis

Full Text

References

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