Download PDF
Thromb Haemost 2001; 85(06): 1120-1121
DOI: 10.1055/s-0037-1615976
Letters to the Editor
Schattauer GmbH

High Prevalence of FVHR2 Polymorphism in Costarician Indians who Have no FVL

F. H. Herrmann
1   Institute of Human Genetics, University Greifswald
,
Lizbeth Salazar-Sanchez
2   CIHATA, University Costa Rica
,
G. Jimenez-Arce
2   CIHATA, University Costa Rica
,
Rita Grimm
1   Institute of Human Genetics, University Greifswald
,
Winnie Schröder
1   Institute of Human Genetics, University Greifswald
› Author Affiliations
Further Information

Publication History

Received 30 October 2000

Accepted after revision 29 January 2001

Publication Date:
12 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Bernardi F, Faioni EM, Castoldi E, Lunghi B, Castaman G, Sacchi E, Mannucci PM. A factor V gene component differing from factor V R506Q contributes to the activated protein C resistance phenotype. Blood 1997; 90: 1553-7.
    PubMedSearch in Google Scholar
  • 2 Lunghi B, Icoviello L, Gemmati D, Dilasio MG, Castoldi E, Pinotti M, Castaman G, Redaelli R, Mariani G, Marchetti G, Bernardi F. Detection of new polymorphic markers in the factor V gene: Association with factor V levels in plasma. Thromb Haemost 1996; 75: 45-8.
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Herrmann FH, Koesling M, Schröder W, Altman R, Jimenez Bonilla R, Lopaciuk S, Perez-Requejo JL, Singh JR. Prevalence of factor V Leiden mutation in various populations. Genet Epidemiol 1997; 14: 403-11.
    CrossrefPubMedSearch in Google Scholar
  • 4 Bertina RM, Koeleman BC, Koster T, Rosendaal RF, Dirven RJ, Ronde de H, Velden van der PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C Nature. 1994 369-64-7.
    PubMedSearch in Google Scholar
  • 5 Lunghi B, Castoldi E, Mingozzi F, Bernardi F. A new factor V gene polymorphism (His1255Arg) present in subjects of african origin mimics the R2 polymorphism (His 1299Arg). Blood 1998; 91: 354-65.
    PubMedSearch in Google Scholar
  • 6 Faioni EM. Factor V HR2: An ancient haplotype out of Africa – reasons for being interested. Thromb Haemost 2000; 83: 358-9.
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Faioni EM, Franchi F, Bucciarelli P, Margaglione M, de Stefano V, Castaman G, Finazzi G, Casorelli I, Mannucci PM. Coinheritence of HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden). Blood 1999; 94: 3062-6.
    PubMedSearch in Google Scholar