Tissue Factor: An Enzyme Cofactor and a True Receptor

James H. Morrissey

doi:10.1055/s-0037-1616202

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2001; 86(01): 66-74
DOI: 10.1055/s-0037-1616202

Research Article

Schattauer GmbH

Tissue Factor: An Enzyme Cofactor and a True Receptor

James H. Morrissey

¹Department of Biochemistry, University of Illinois College of Medicine at Urbana-Champaign, Urbana, IL, USA

› Institutsangaben

Abstract

Summary

Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many – perhaps most – thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.

Key words

Tissue factor - Factor VII - Factor VIIa - TFPI - Thrombotic risk factors

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References
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