A Journey with Platelet P-Selectin: The Molecular Basis of Granule Secretion, Signalling and Cell Adhesion

Bruce Furie; Barbara C. Furie; Robert Flaumenhaft

doi:10.1055/s-0037-1616219

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(01): 214-221
DOI: 10.1055/s-0037-1616219

Research Article

Schattauer GmbH

A Journey with Platelet P-Selectin: The Molecular Basis of Granule Secretion, Signalling and Cell Adhesion

Bruce Furie

¹Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

,

Barbara C. Furie

¹Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

,

Robert Flaumenhaft

¹Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

› Author Affiliations

Abstract

Summary

P-selectin is a transmembrane protein that resides within the alpha granule membrane of unstimulated platelets. The “extracellular” domains face into the lumen of the granule and the cytoplasmic tail extends into the platelet cytoplasm. Upon platelet stimulation, P-selectin is phosphorylated and translocated to the plasma membrane via a secretory pathway. P-selectin in the plasma membrane surface is exposed and serves as a cell adhesion receptor to interact with other cell receptors, including PSGL-1 and GPIb. P-selectin upregulates tissue factor in monocytes and leads to leukocyte accumulation in areas of vascular injury associated with thrombosis and inflammation.

Key words

P-selectin - selectin - PSGL-1 - platelet - alpha granule

Full Text

References

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