Obesity and vascular risk

H. R. Lijnen

doi:10.1055/s-0037-1616938

Hämostaseologie, Inhaltsverzeichnis

Hamostaseologie 2009; 29(01): 44-45
DOI: 10.1055/s-0037-1616938

Original article

Schattauer GmbH

Obesity and vascular risk

H. R. Lijnen

¹Center for Molecular and Vascular Biology, KU Leuven, Belgium

› Institutsangaben

Abstract

Summary

Obesity is a common disorder and a known risk factor for vascular thrombotic complications. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. Studies using a nutritionally induced obesity model in transgenic mice support a role of the fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems in these processes. Venous or arterial thrombosis models in obese mice confirm a prothrombotic risk associated with obesity.

Keywords

Obesity - adipose tissue - thrombosis - proteolysis

Volltext

Referenzen

References
1 Canonico M, Oger E, Conard J. et al. EStrogen and THromboEmbolism Risk (ESTHER) study. J Thromb Haemost 2006; 4: 1259-1265.
2 Christiaens V, Scroyen I, Lijnen HR. Role of proteolysis in development of murine adipose tissue. Thromb Haemost 2008; 99: 290-294.
3 Crandall DL, Hausman EJ, Kral JG. A review of the microcirculation of adipose tissue. Micro -circulation 1997; 4: 211-232.
4 Demeulemeester D, Scroyen I, Voros G. et al. Overexpression of tissue inhibitor of matrix metalloproteinase-1 in mice does not affect adipo-genesis or adipose tissue development. Thromb Haemost 2006; 95: 1019-1024.
5 Gomez DE, Alonso DF, Yoshiji H. et al. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur J Cell Biol 1997; 74: 111-122.
6 Hoover-Plow J, Ellis J, Yuen L. In vivo plasminogen deficiency reduces fat accumulation. Thromb Haemost 2002; 87: 1011-1019.
7 Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
8 Lijnen HR, Van Hoef B, Frederic L. et al. Adipocyte hypertrophy in stromelysin-3 deficient mice with nutritionally induced obesity. Thromb Haemost 2002; 87: 530-535.
9 Lijnen HR, Maquoi E, Morange PE. et al. Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 2003; 23: 78-84.
10 Lijnen HR, Demeulemeester D, Van Hoef B. et al. Deficiency of tissue inhibitor of matrix metalloproteinase-1 impairs nutritionally induced obesity in mice. Thromb Haemost 2003; 89: 249-255.
11 Lijnen HR, Collen D. Molecular and celluar basis of fibrinolysis. In: Hoffman R, Benz EJ, Shattil SJ. et al (eds). Hematology: basic principles and practice. Philadelphia: Elsevier; 2005: 1955-1959.
12 Lijnen HR. Pleiotropic functions of plasminogen activator inhibitor-1. J Thromb Haemost 2005; 3: 35-45.
13 Lijnen HR. Effect of plasminogen activator inhibitor-1 deficiency on nutritionally-induced obesity in mice. Thromb Haemost 2005; 93: 816-819.
14 Lijnen HR. Deficiency of α2-antiplasmin does not affect murine adipose tissue development. Thromb Haemost 2007; 5: 420-421.
15 Maquoi E, Munaut C, Colige A. et al. Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes 2002; 51: 1093-1101.
16 Maquoi E, Demeulemeester D, Voros G. et al. Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation. Thromb Haemost 2003; 89: 696-704.
17 Morange PE, Bastelica D, Bonzi MF. et al. Influence of t-PA and u-PA on adipose tissue development in a murine model of diet-induced obesity. Thromb Haemost 2002; 87: 306-310.
18 Nagai N, Van Hoef B, Lijnen HR. Plasminogen activator inhibitor-1 contributes to the deleterious effect of obesity on the outcome of thrombotic ischemic stroke in mice. J Thromb Haemost 2007; 5: 1726-1731.
19 Nagai N, Hoylaerts MF, Cleuren AC. et al. Obesity promotes injury induced femoral artery thrombosis in mice. Thromb Res 2008; 122: 549-555.
20 Pomp ER, le Cessie S, Rosendaal FR. et al. Risk of venous thrombosis. Br J Haematol 2007; 139: 289-296.
21 Scroyen I, Jacobs F, Cosemans L. et al. Tissue inhibitor of matrix metalloproteinases-1 affects angiogenesis during adipocyte differentiation in vivo. J Thromb Haemost. 2008 6 (Suppl 1).
22 Van Hul M, Lijnen HR. A functional role of gelatinase A in the development of nutritionally induced obesity in mice. J Thromb Haemost 2008; 6: 1198-1206.