Thrombotische Mikroangiopathien

J.-D. Studt

doi:10.1055/s-0037-1617183

Hämostaseologie, Table of Contents

Hamostaseologie 2008; 28(05): 358-364
DOI: 10.1055/s-0037-1617183

Hämostaseologie

Schattauer GmbH

Thrombotische Mikroangiopathien

Thrombotic microangiopathies

J.-D. Studt

¹Abteilung für Hämatologie, Universitätsspital Basel, Schweiz

› Author Affiliations

Abstract

Zusammenfassung

Thrombotische Mikroangiopathien sind durch mikrovaskuläre Okklusion gekennzeichnet. Klinisch finden sich eine Thrombozytopenie und mikroangiopathische hämolytische Anämie. Zusätzliche Symptome der Organischämie können in variabler Konstellation ausgeprägt sein. Die thrombotischen Mikroangiopathien sind pathophysiologisch heterogen. Sie umfassen die thrombotisch-thrombozytopenische Purpura und das hämolytisch-urämische Syndrom. Daneben sind eine Assoziation mit verschiedenen Erkrankungen und Medikamenten und ein Auftreten nach allogener hämatopoetischer Stammzelltransplantation bekannt.

Summary

Thrombotic microangiopathies are disorders of microvascular occlusion and are characterized by thrombocytopenia and microangiopathic haemolytic anaemia. Varying additional signs and symptoms of organ ischaemia may be present. Thrombotic microangiopathies are pathophysiologically heterogenous disorders and include primarily thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome. Besides this, they may occur in association with certain diseases or drugs, or after allogeneic haematopoietic stem cell transplantation.

Schlüsselwörter

Thrombotische Mikroangiopathie - thrombotisch-thrombozytopenische Purpura - hämolytisch-urämisches Syndrom

Keywords

Thrombotic microangiopathy - thrombotic thrombocytopenic purpura - haemolytic uraemic syndrome

Full Text

References

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