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Nuklearmedizin 1978; 17(06): 266-269
DOI: 10.1055/s-0037-1620705
Originalarbeiten – Original Articles
Schattauer GmbH

Microautoradiographic Studies on the Cellular Localization of Radiothallium[*]

Mikroautoradiographische Untersuchungen der zellulären Verteilung von Radiothallium
P. Som
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
K. Matsui
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
H.L. Atkins
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
E. Lebowtiz
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
D.D. Greenberg
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
A.N. Ansari
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
J.F. Klopper
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
D.F. Sacker
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
,
L.F. Hathorn
1   From the Brookhaven National Laboratory, Upton, N. Y., and the New England Nuclear Corporation*, North Billerica, Mass., USA
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Publikationsverlauf

Received: 12. Juni 1978

Publikationsdatum:
09. Januar 2018 (online)

    Lizenzen und Reprints

201Tl-chloride and 204Tl-nitr-ate were similarly distributed in organs of mice 10 min and 60 min after intravenous injection. Autoradiographic studies were carried out with 204Tl-nitrate in rats (injected intraperitoneally) as well as in mice and dogs (injected intravenously). Thallium localized in the cells of proximal and distal convoluted tubules and collecting tubules of the kidney. In the intestines, it was distributed mostly in the cells of the smooth musculature and surface epithelium of the villi. Some silver grains were seen in the goblet cells and in the lumen as well. It localized in the sarcoplasm of the myocardium and the skeletal muscle cells. In thyroid, most of the thallium was seen in the colloidal part of the follicle. In testes, silver grains were seen in and around the cells of Sertoli and in the lumen of the seminiferous tubules. Some localized concentration in the interstitial cells of the testes was also observed.

Die Organverteilung von 201Tl-chlorid und 204T1-Nitrat wurde 10 und 60 Min. nach intravenöser Injektion bei Mäusen untersucht. Die Organverteilung der beiden Thalliumisotope war ähnlich. Autoradiographische Untersuchungen wurden mit 204T1 an Ratten (intraperitoneale Injektion) sowie Hunden und Mäusen (intravenöse Injektion) durchgeführt. Thallium fand sich in Zellen der proximalen und distalen Nierentubuli sowie in den Sammelröhrchen der Nieren. Im Darm war das Isotop hauptsächlich in den glatten Muskelzellen und im Zottenepithel zu finden. Gelegentliche Silberkörnchen kamen auch in Becherzellen sowie im Darmlumen vor. Herzmuskelzellen und Skeletmuskelzellen enthielten Thallium. In der Schilddrüse wurde das Isotop besonders im Follikelinhalt angereichert gefunden. In den Testes wurden Silberkörnchen in und um die Sertolischen Zellen und im Lumen der Tubuli seminiferi gesehen. Auch die interstitiellen Zellen der Testes zeigten gelegentliche Ansammlungen von Thallium.

* Research Supported by United States Department of Energy and NIH Grant #2R01HL16553–0 4


 

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