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Nuklearmedizin 2004; 43(01): 33-42
DOI: 10.1055/s-0038-1623912
DOI: 10.1055/s-0038-1623912
Original Article
PET in neuroscience
Dopaminergic, GABA/benzodiazepine, and opiate systemPET in den Neurowissenschaftendopaminerges, GABA/Benzodiazepin- und OpiatsystemP. Bartenstein
1
Klinik und Poliklinik für Nuklearmedizin, Johannes-Gutenberg-Universität Mainz
› Author Affiliations
Further Information
Publication History
Eingegangen:
24 September 2003
24 September 2003
Publication Date:
11 January 2018 (online)
Summary
This article gives an overview on radiotracer imaging with positron emission tomography (PET) in measuring various aspects of neurotransmission. The review focusses on the dopaminergic system, the GABA/benzodiazepine system, and the opiate system. Besides dealing with the current clinical applications for brain PET studies with specific radiopharmaceuticals this article outlines an idea on potential future developments for the use of these methods in basic neuroscience.
Zusammenfassung
Diese Arbeit präsentiert eine Übersicht zur aktuellen Forschung und klinischen Anwendung von PET-Untersuchungen mit Radiopharmaka, die verschiedene Komponenten der Neurotransmission erfassen. Außerdem werden Perspektiven und Trends der Methodik gezeigt. Im Mittelpunkt stehen das dopaminerge System, das GABA/Benzodiazepinsystem, und das Opiatsystem. Ausführlich dargestellt werden aktuelle klinische und kliniknahe Möglichkeiten sowie methodische Aspekte der grundlagenorientierten Forschung, die für eine zukunftsorientierte Anwendung von PET-Studien mit Rezeptorliganden u. a. Radiopharmaka zur Bildgebung komplexer biochemischer Prozesse von Bedeutung sind.
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