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Tierarztl Prax Ausg G Grosstiere Nutztiere 2009; 37(04): 236-241
DOI: 10.1055/s-0038-1623961
Original article
Schattauer GmbH

Clinical, haematological and biochemical findings in Saanen goat kids with naturally occurring heat stroke

Klinische, hämatologische und biochemische Befunde bei Saanen-Ziegen-lämmern nach natürlich auftretendem Hitzschlag
E. M. Temizel
1   Uludag University, Faculty of Veterinary Medicine, Department of International Medicine, Görükle Kampusu, Veteriner Fakultesi Hayvan Hastanesi, Nilufer/Bursa Turkey
,
S. Senturk
1   Uludag University, Faculty of Veterinary Medicine, Department of International Medicine, Görükle Kampusu, Veteriner Fakultesi Hayvan Hastanesi, Nilufer/Bursa Turkey
,
S. Kasap
1   Uludag University, Faculty of Veterinary Medicine, Department of International Medicine, Görükle Kampusu, Veteriner Fakultesi Hayvan Hastanesi, Nilufer/Bursa Turkey
› Author Affiliations
Further Information

Publication History

Received: 17 November 2008

Accepted: 31 March 2009

Publication Date:
10 January 2018 (online)

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Summary

Objective: Description of clinical, biochemical and haematological changes in Saanen goat kids post-exposure to a naturally occurring heat stroke. Material and methods: The experimental group consisted of goats of different age (1–4 months) and sex (8 males, 12 females) with an average weight of 7.2 ± 3.1 kg. Twenty clinically healthy, three to four months old, Saanen goat kids (sex-ratio 1:1) were used as a control. The average body weight in this group was 9.4 ± 2.6 kg. Case history, clinical signs, and results of haematology and blood biochemistry were documented in all goat kids. Results: Most common findings were hyperthermia, ataxia, muscle tremor and depression. Increased serum urea, creatinine, potassium and plasma lactate concentrations as well as an increase in aspartate aminotransferase and lactate dehydrogenase activity were observed in goats post-exposure to heat stroke when compared to the control group. Two goat kids died despite supportive treatment. Physical and biochemical blood parameters improved following treatment. Conclusion: This is the first study on heat stroke in Saanen goat kids. Heatstroke may be fatal in Saanen goat kids, despite appropriate treatment, and may lead to secondary complications. Plasma lactate concentration seems to be a reliable indicator for the prognosis of heat stroke in goat kids.

Zusammenfassung

Gegenstand und Ziel: Beschreibung der klinischen, biochemischen und hämatologischen Veränderungen bei Saanen-Ziegenlämmern nach natürlich auftretendem Hitzschlag. Material und Methoden: Bei 20 Ziegenlämmern, bei denen unter natürlichen Bedingungen ein Hitzschlag auftrat, wurden neben Vorbericht und klinischen Symptomen die Ergebnisse hämatologischer und biochemischer Blutuntersuchungen erfasst und den Werten von Kontrolltieren gegenübergestellt. Die von einem Hitzschlag betroffenen Ziegenlämmer (1–4 Monate, 8 männlich, 12 weiblich) hatten ein Durchschnittsgewicht von 7,2 ± 3,1 kg. Die Kontrollgruppe bestand aus 20 gesunden Ziegenlämmern (3–4 Monate, 10 männlich, 10 weiblich) mit einem Körpergewicht von 9,4 ± 2,6 kg. Ergebnisse: Die wichtigsten klinischen Symptome der von einem Hitzschlag betroffenen Tiere waren Hyperthermie, Ataxie, Inkoordination, Muskelzittern und Depression. Im Vergleich zu den Kontrolltieren wiesen sie erhöhte Serumharnstoff-, -kreatinin-, -kalium- und Plasmalaktatkonzentrationen sowie erhöhte AST- und LDH-Aktivitäten auf. Zwei Ziegenlämmer starben trotz Behandlung. Bei den überlebenden Tieren führte die Therapie zu einer deutlichen Besserung der klinischen Symptomatik und der biochemischen Parameter. Schlussfolgerung: Dies ist die erste Studie, die die Auswirkung eines Hitzschlags bei Saanen- Ziegenlämmern beschreibt. Die Bestimmung der Laktatkonzentration im Plasma scheint ein wertvoller Indikator für die Prognose zu sein.

Key words

Caprine - heat stroke - hyperthermia - blood biochemical parameters

Schlüsselwörter

Ziegenlämmer - Hitzschlag - Hyperthermie - biochemische Parameter
 

  • References

  • 1 Abdel-Samee AM, Kamal TH, Abu-Sinna G, Hagag AM. Alleviation of the heat load on lactating goats with the use of diuretics and drinking cool water. Beitr Trop Landwirtsch Veterinarmed 1992; 30: 91-99.
    PubMedGoogle Scholar
  • 2 Al-Tamimi HJ. Thermoregulatory response of goat kids subjected to heat stress. Small Rumin Res 2007; 71: 280-285.
    CrossrefPubMedGoogle Scholar
  • 3 Alzeer AH, Al-Arifi A, Warsy AS, Ansari Z, Zhang H, Vincent JL. Nitric oxide production is enhanced in patients with heat stroke. Intensive Care Med 1999; 25: 58-62.
    CrossrefPubMedGoogle Scholar
  • 4 Alzeer AH, El-Hazmi MAF, Warsy AS, Ansari ZA, Yrkendi MS. Serum enzymes in heat stroke: prognostic implication. Clin Chem 1997; 43: 1182-1187.
    CrossrefPubMedGoogle Scholar
  • 5 Amemiya T. Differences in muscular changes in rats with vitamin E and with selenium deficiency. Int J Vitam Nutr Res 1987; 57: 139-143.
    PubMedGoogle Scholar
  • 6 Baccari Jr F, Johnson HD, Hahn GL. Environmental heat effects on growth, plasma T3, and postheat compensatory effects on Holstein calves. Proc Soc Exp Biol Med 1983; 173: 312-318.
    CrossrefPubMedGoogle Scholar
  • 7 Backer HD, Shopes E, Collins SL, Barkan H. Exertional heat illness and hyponatremia in hikers. Am J Emerg Med 1999; 1: 532-539.
    PubMedGoogle Scholar
  • 8 Baker MA. Effects of dehydration and rehydration on thermoregulatory sweating in goats. J Physiol 1989; 417: 421-435.
    CrossrefPubMedGoogle Scholar
  • 9 Barrow MW, Clark KA. Heat-related illnesses. Am Fam Physician 1998; 58: 749-759.
    PubMedGoogle Scholar
  • 10 Boersma LVA, Leyten QH, Meijer JWR, Strubbe EJ, Bosch FH. Cerebral haemorrhage complicating exertional heat stroke. Clin Neurol Neurosurg 1998; 100: 112-115.
    CrossrefPubMedGoogle Scholar
  • 11 Bouchama A, Cafege A, Robertson W, Al-Dossary S, El-Yazigi A. Mechanisms of hypophosphatemia in humans with heatstroke. J Appl Physiol 1991; 71: 328-332.
    CrossrefPubMedGoogle Scholar
  • 12 Bouchama A, Knochel JP. Heat stroke. N Engl J Med 2002; 346: 1978-1988.
    CrossrefPubMedGoogle Scholar
  • 13 Bouchama A, Roberts G, Al Mohanna F. Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke. J Appl Physiol 2004; 98: 697-705.
    PubMedGoogle Scholar
  • 14 Bricknell MCM. Heat illness – a review of military experience (Part 1). J R Army Med Corps 1995; 141: 157-166.
    CrossrefPubMedGoogle Scholar
  • 15 Bruchim Y, Klement E, Saragusty J, Finkeilstein E, Kass P, Aroch I. Heat stroke in dogs: A retrospective study of 54 cases (1999–2004) and analysis of risk factors for death. J Vet Intern Med 2006; 20: 38-46.
    PubMedGoogle Scholar
  • 16 Cecil RL, Wyngaarden JB, Smith LH, Bennett JC. In Cecil Textbook of Medicine, 19th ed. Philadelphia: Saunders; 1992: 2358-2361.
    Google Scholar
  • 17 Damanhouri ZA, Tayeb OS. Animal models for heat stroke studies. J Pharmacol Toxicol 1992; 28: 119-127.
    CrossrefPubMedGoogle Scholar
  • 18 Dematte JE, O’Mara K, Buescher J. Near-fatal heat stroke during the 1995 heat wave in Chicago. Ann Intern Med 1998; 129: 173-81.
    CrossrefPubMedGoogle Scholar
  • 19 Drobatz KJ, Macintire DK. Heat-induced illness in dogs: 42 cases (1976–1993). J Am Vet Med Assoc 1996; 209: 1894-1899.
    PubMedGoogle Scholar
  • 20 Flournoy S, Macintire DK, Wohl J. Heatstroke in dogs: Clinical signs, treatment, prognosis, and prevention. Compendium 2003; 25: 422-431.
    PubMedGoogle Scholar
  • 21 Giercksky T, Boberg KM, Farstad IN, Halvorsen S, Schrumpf E. Severe liver failure in exertional heat stroke. Scand J Gastroenterol 1999; 34: 24-27.
    PubMedGoogle Scholar
  • 22 Grogan H, Hopkins PM. Heat stroke: implications for critical care and anaesthesia. Br J Anaesth 2002; 88: 700-707.
    CrossrefPubMedGoogle Scholar
  • 23 Hew-Butler T, Sharwood K, Boulter J, Collins M, Tucker R, Dugas J. et al. Dysnatremia predicts a delayed recovery in collapsed ultramarathon runners. Clin Sports Med 2007; 17: 289-96.
    CrossrefPubMedGoogle Scholar
  • 24 Howorth PJN. The biochemistry of heat illness. J R Army Med Corps 1995; 141: 40-41.
    CrossrefPubMedGoogle Scholar
  • 25 Jessen C. Interaction of air temperature and core temperatures in thermoregulation of the goat. J Physiol 1977; 264: 585-606.
    CrossrefPubMedGoogle Scholar
  • 26 Jones TS, Liang AP, Kilbourne EM, Griffin MR, Patriarca PA, Wassilak SG. et al. Morbidity and mortality associated with the July 1980 heat wave in St Louis and Kansas City, Mo. JAMA 1982; 247: 3327-3331.
    CrossrefPubMedGoogle Scholar
  • 27 Kasahara T, Ozawa T, Tamura K, Shibata A, Muto N. A case of sunstroke with elevation of multiple serum emzymes. Nihon Naika Gakkai Zasshi 1979; 10: 1126-1132.
    PubMedGoogle Scholar
  • 28 Katamoto H, Fukuda H, Oshima I, Ishikawa N, Kanai Y. Nitroblue tetrazolium reduction of neutrophils in heat stressed goats is not influenced by selenium and vitamin E injection. J Vet Med Sci 1998; 60: 1243-1249.
    CrossrefPubMedGoogle Scholar
  • 29 Knochel JP. Exertional heat stroke-pathophysiology of heat stroke. In: Hyperthermic and Hypermetabolic Disorders, 2nd ed. Hopkins PM, Ellis FR. eds. Cambridge: Cambridge University Press; 1996: 42-62.
    Google Scholar
  • 30 Lee-Chiong TL, Stitt JT. Heatstroke and other heat-related illnesses. The maladies of summer. Postgrad Med 1995; 98: 26-36.
    CrossrefPubMedGoogle Scholar
  • 31 Marai IFM, Ei-Darawany AA, Fadiel A, Abdel Hafez MAM. Physiological traits as affected by heat stress in sheep. A review. Small Rumin Res 2006; 71: 11-12.
    PubMedGoogle Scholar
  • 32 Mehta SR, Jaswal DS. Heat Stroke. Armed Forces Med J India 2003; 59: 140-143.
    PubMedGoogle Scholar
  • 33 Mellion M, Shelton G. Thermoregulation, heat illness, and safe exercise in heat. In: Office Sports Medicine. Mellion M. ed. Philadelphia: Mosby; 1998: 45-57.
    Google Scholar
  • 34 Pugh DG. Sheep and Goat Medicine: Normal Values and Conversions, 1nd ed. Philadelphia: Elsevier; 2002: 451-452.
    Google Scholar
  • 35 Radostitis OM, Blood DC, Gay CC, Hinchcliff KW. 2000. General systemic states, hypothermia, hyperthermia, fever. In: Textbook of Veterinary Medicine, 9th ed. Philadelphia: Saunders,; 2004
    Google Scholar
  • 36 Reda G, Kumar SA. Acute renal failure due to rhabdomyolysis caused by hypokalemia. Saudi J Kidney Dis Transpl 2001; 12: 187-190.
    PubMedGoogle Scholar
  • 37 Robertshaw D, Taylor CR. A comparison of sweat gland activity in eight species of east african bovids. J Physiol 1969; 203: 135-143.
    CrossrefPubMedGoogle Scholar
  • 38 Senturk S. Clinical evaluation of prognostic factors in equine colic. Indian Vet J 2003; 80: 275-276.
    PubMedGoogle Scholar
  • 39 Shafie MM, Abdelghany FM. Structure of the respiratory system of sheep as related to heat tolerance. Acta Anat 1978; 100: 441-460.
    CrossrefPubMedGoogle Scholar
  • 40 Silanikove N. Effects of heat stress on the welfare of extensively managed domestic ruminants. Livest Prod Sci 2000; 67: 1-18.
    CrossrefPubMedGoogle Scholar
  • 41 Silanikove N. Impact of shelter in hot Mediterranean climate on feed intake, feed utilization and body fluid distribution in sheep. Appetite 1987; 9: 207-215.
    CrossrefPubMedGoogle Scholar
  • 42 SPSS 13.0 for Windows Evaluation version. (SPSS Inc., Illinois, USA)
    PubMed
  • 43 Symonds ME, Lomax MA. Maternal and environmental influences on thermoregulation in the neonate. Proceedings of the Nutrition Society 1992; 51: 165-172.
    CrossrefPubMedGoogle Scholar
  • 44 Tayeb OS, Marzouki ZM. Effect of dantrolene pretreatment on heatstroke in sheep. Pharmacol Res 1990; 22: 565-572.
    CrossrefPubMedGoogle Scholar
  • 45 Tucker LE, Stanford J, Graves B, Swetnam J, Hamburger S, Anwar A. Classical heatstroke: clinical and laboratory assessment. South Med J 1985; 78: 20-25.
    CrossrefPubMedGoogle Scholar
  • 46 Turkish Meteorological Service, http://tumas.meteoroloji.gov.tr/wps/portal July, 2007
    PubMed
  • 47 van Der Linde A, Kielblock AJ, Rex DA, Terblanche SE. Diagnostic and prognostic criteria for heatstroke with special reference to plasma enzyme and isoenzyme release patterns. Int J Biochem 1992; 24: 477-485.
    CrossrefPubMedGoogle Scholar
  • 48 Wexler RK. Evaluation and treatment of heat-related illnesses. Am Fam Physician 2002; 65: 2307-2314.
    PubMedGoogle Scholar