Studies on the Relationship between 67Ga-Citrate Accumulation and Calcium Metabolism in Tumor Cells

Leopoldo J. Anghileri

doi:10.1055/s-0038-1624827

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1973; 12(03): 240-251
DOI: 10.1055/s-0038-1624827

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Studies on the Relationship between ⁶⁷Ga-Citrate Accumulation and Calcium Metabolism in Tumor Cells

Etude sur la relation entre la fixation du citrate de 67 gallium et le métabolisme du calcium dans des cellules tumoralesUntersuchungen über die Beziehung zwischen ⁶⁷Ga-zitrat-Aufnahme und Kalziumstoffwechsel in Tumorzellen

Leopoldo J. Anghileri^*

¹Innere Klinik und Poliklinik (Tumorforschung); Klinikum der Gesamthochschule Essen (Direktor: Prof. Dr. C. G. Schmidt)

› Author Affiliations

Abstract

L’incorporation in vivo du citrate de gallium (⁶⁷Ga) et du chlorure de calcium (⁴⁵Ca) dans les cellules de la tumeur ascitique d’Ehrlich a été étudiée par la technique des “ghost cells”. Les résultats indiquent qu’à peu près 50% du ⁶⁷Ga intracellulaire est incorporé par le matérial cellulaire résiduel qui ist formé principalement par des phospholipides, protéines et acides nucléiques. La relation existant entre les deux incorporations (du ⁶⁷Ga et du ⁴⁵Ca) est discutée.

Summary

The in vivo uptake of ⁶⁷Ga-citrate and ⁴⁵Ca-chloride by Ehrlich ascites tumor cells has been studied by the "ghost cells" technique. The results indicate that approximately 50% of the intracellular ⁶⁷Ga is incorporated into the cellular residual material formed mainly by phospholipids, proteins and nucleic acids. The relationship between both ⁶⁷Ga and ⁴⁵Ca incorporations is discussed.

Die in vivo “uptake” von ⁶⁷Ga-Zitrat und ⁴⁵Ca-Chlorid in Ehrlich-Aszites- Tumorzellen wurde anhand der “ghost cells”-Technik untersucht. Die Ergebnisse lassen erkennen, daß annähernd 50% des intrazellulären ⁶⁷Ga im zellulären Restmaterial, das hauptsächlich aus Phospholipiden, Proteinen und Nukleinsäuren besteht, gespeichert werden. Die Beziehungen zwischen ⁶⁷Ga- und ⁴⁵Ca- Speicherung werden diskutiert.

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References

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