Medikamentöse Therapie von Hirntumoren

B. E. Stopschinski; D. Beier; C. P. Beier

doi:10.1055/s-0038-1628288

Nervenheilkunde, Table of Contents

Nervenheilkunde 2012; 31(09): 621-629
DOI: 10.1055/s-0038-1628288

Neuroonkologie

Schattauer GmbH

Medikamentöse Therapie von Hirntumoren

Medicinal therapy of brain tumors

B. E. Stopschinski

¹Neurologische Universitätsklinik, RWTH Aachen

,

D. Beier

¹Neurologische Universitätsklinik, RWTH Aachen

,

C. P. Beier

¹Neurologische Universitätsklinik, RWTH Aachen

› Author Affiliations

Abstract

Zusammenfassung

Die Chemotherapie zählt zur Standardtherapie vieler Hirntumore. In der Behandlung der häufigsten Hirntumore, den zerebralen Gliomen, kommt der Chemotherapie ein wichtiger Stellenwert zu. Studien untersuchen die prognostische und therapeutische Relevanz verschiedener molekularer Marker in der Gliomtherapie, wie den LOH-1p/19q-Status, Mutationen des Isocitratdehydrogenasegens sowie die Methylierung des MGMT-Promotors. Neue Substanzen aus dem Bereich der Immuntherapie, der Virotherapie und der Angiogenesehemmung werden auf ihre Wirksamkeit in vorklinischen und klinischen Studien überprüft. Für die selteneren Hirntumore, wie die pilozytischen Astrozytome, Ependymome und Medulloblastome fehlen größere Studien zur Relevanz der Chemotherapie. Sie nimmt jedoch eine Schlüsselrolle in der Therapie der primären ZNS-Lymphome ein.

Summary

Chemotherapy has become part of the standard treatment for many brain tumors. It plays an important role in the therapy oft the most common brain tumors, the gliomas. Several ongoing studies investigate the prognostic and therapeutic relevance of different molecular markers in glioma therapy, such as the LOH 1p/19q status or the presence of isocitrate dehydrogenase mutations and MGMT promoter methylation. New therapeutic approaches from immunotherapy, virotherapy, and inhibition of angiogenesis are currently under investigation in preclinical and clinical studies. For the more seldom-occurring brain tumors, such as pilocytic astrocytomas, ependymomas and medulloblastomas, large studies concerning the relevance of chemotherapy are lacking. However, chemotherapy plays a key role in the treatment of primary CNS lymphomas.

Schlüsselwörter

Neuroonkologie - Chemotherapie - Hirntumor - Temozolomid - Glioblastom - LOH 1p/19q - IDH1 - MGMT

Keywords

Neurooncology - chemotherapy - brain tumor - temozolomide - glioblastoma - LOH 1p/19q - IDH1 - MGMT

Full Text

References

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