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Nuklearmedizin 1991; 30(05): 183-188
DOI: 10.1055/s-0038-1629573
ÜBersichtsartikel - Review Articles
Schattauer GmbH

Left Ventricular Dysfunction and Blood Glycohemoglobin Levels in Young Diabetics

Linksventrikuläre Dysfunktion und Blutglykohämoglobinwerte bei jungen Diabetikern
A. Aydrner
1   From the Departments of Cardiology, Ankara, Turkey
,
T. Aras
2   From the Departments of Nuclear Medicine, Ankara, Turkey
,
A. Oto
1   From the Departments of Cardiology, Ankara, Turkey
,
E. Oram
1   From the Departments of Cardiology, Ankara, Turkey
,
O. Gedik
3   From the Departments of Endocrinology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
,
C. F. Bekdik
2   From the Departments of Nuclear Medicine, Ankara, Turkey
,
A. Oram
1   From the Departments of Cardiology, Ankara, Turkey
,
S. Ugurlu
1   From the Departments of Cardiology, Ankara, Turkey
,
A. Karamehmetoglu
1   From the Departments of Cardiology, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

Received: 15 April 1991

in revised form: 28 June 1991

Publication Date:
05 February 2018 (online)

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Left ventricular function including regional wall motion (RWM) was evaluated by 99mTc first-pass and equilibrium gated blood pool ventriculography and glycohemoglobin (HbA1c) blood levels determined by a quantitative column technique in 25 young patients with insulin-dependent diabetes mellitus without clinical evidence of heart disease, and in healthy controls matched for age and sex. Phase analysis revealed abnormal RWM in 19 of 21 diabetic patients. The mean left ventricular global ejection fraction, the mean regional ejection fraction and the mean 1/3 filling fraction were lower and the time to peak ejection, the time to peak filling and the time to peak ejection /cardiac cycle were longer in diabetics than in controls. We found high HbA1c levels in all diabetics. There was no significant difference between patients with and without retinopathy and with and without peripheral neuropathy in terms of left ventricular function and HbA1c levels.

Zusammenfassung

Es wurden mittels 99mTc-Ventrikulographie die linksventrikulären Funktionsparameter, einschließlich der regionalen Wandbewegung (RWM), und mittels einer quantitativen Säulentechnik die Glykohämoglobin-Werte (HbAlc) im Blut bei 25 jungen Patienten mit insulinabhängigem Diabetes mellitus ohne klinische Zeichen einer Herzerkrankung bestimmt; als Kontrolle dienten Gesunde passenden Geschlechts und Alters. Die Phasenanalyse zeigte bei 19/21 Diabetikern abnorme RMWs. Die mittlere linksventrikuläre globale Auswurffraktion, die mittlere regionale Auswurffraktion und die mittlere 1/3 Füllungsfraktion waren bei den Diabetikern niedriger und die “Time to Peak Ejection”, die “Time to Peak Filling” und die “Time to Peak Ejection” pro Herzschlag länger als bei den Kontrollen. Die HbAlc-Werte waren bei allen Diabetikern erhöht. Hinsichtlich der linksventrikulären Funktion und der HbAlc-Werte fand sich kein signifikanter Unterschied zwischen Patienten mit und ohne Retinopathie bzw. mit und ohne neurologische Störungen.

 

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