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Vet Comp Orthop Traumatol 1993; 06(03): 166-171
DOI: 10.1055/s-0038-1633117
Review Article
Schattauer GmbH

Bone Morphogenetic Proteins and Bone Derived Growth Factors

Elaine B. Forell
1   Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
,
R. C. Straw
1   Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
› Author Affiliations
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Publication History

Received for publication 20 November 1992

Publication Date:
09 February 2018 (online)

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Summary

Recent studies suggest that local control of bone homeostatic and reparative mechanisms is most likely attributable to the interrelated function of a number of bone morphogenetic proteins (BMP) and bone derived growth factors. While osteogenesis is believed to be initiated by BMP, bone growth factors are thought to play a role in the promotion and maintenance of the newly induced bone and in the regulation of normal bone remodeling and repair. An overview of the current literature pertaining to BMP and the various bone derived growth factors is presented.

While osteogenesis is believed to be initiated by bone morphogenetic proteins, bone growth factors are thought to play a role in the maintenance of the newly induced bone and in the regulation of normal bone remodeling and repair. Current research suggests that, in the future, these substances may be used as systemic or locally administered adjuvant therapy in order to accelerate bone regeneration and fracture healing.

Keywords

Bone - growth factors - bone morphogenetic proteins
 

  • REFERENCES

  • 1 Mohan S, Baylink DJ. Bone growth factors. Clin Orthop 1991; 263: 30.
    PubMedGoogle Scholar
  • 2 Boskey AL. Noncollagenous matrix proteins and their role in mineralization. Bone Miner 1989; 6: 111.
    CrossrefPubMedGoogle Scholar
  • 3 Fetter AW. Normal bone anatomy. In: Textbook of Small Animal Orthopedics. Newton CD, Nunamaker DM. (ed). Philadelphia: Lippincott; 1985: 9-12.
    Google Scholar
  • 4 Mohan S, Linkhart TA, Jennings JC, Bay-link DJ. Identification and quantification of four distinct growth factors stored in human bone matrix. Proc 34th Ann Meeting Orthop Res Soc 1988: 322.
    PubMedGoogle Scholar
  • 5 Ekelund A, Brosjo O, Nilsson O. Experimental induction of heterotopic bone. Clin Orthop 1991; 263: 102.
    PubMedGoogle Scholar
  • 6 Urist MR. Bone: Formation by autoinduction. Science 1965; 150: 893.
    CrossrefPubMedGoogle Scholar
  • 7 Urist MR, Delange RJ, Finerman GAM. Bone cell differentiation and growth factors. Science 1983; 220: 680.
    CrossrefPubMedGoogle Scholar
  • 8 Urist MR. Bone morphogenetic protein induced bone formation and the bone -bone marrow consortium. In: Bone Transplantation. Aebi M, Regazzoni P. (ed). Berlin: Springer; 1989: 185-197.
    CrossrefGoogle Scholar
  • 9 Wang EA, Rosen V, Cordes P. et al. Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci USA 1988; 85: 9484.
    CrossrefPubMedGoogle Scholar
  • 10 Wozney JM, Rosen V, Celeste AJ. et al. Novel regulators of bone formation: Molecular clones and activities. Science 1989; 242: 1528.
    PubMedGoogle Scholar
  • 11 Katz RW, Reddi AH. Dissociative extraction and partial purification of osteogenin, a bone inductive protein, from rat tooth matrix by heparin affinity chromatography. Biochem Biophys Res Commun 1988; 157: 1253.
    CrossrefPubMedGoogle Scholar
  • 12 Reddi AH, Cunningham NS. Bone induction by osteogenin and bone morphogenetic proteins. Biomaterials 1990; 11: 33.
    PubMedGoogle Scholar
  • 13 Bentz H, Nathan RM, Rosen DM. et al. Purification and characterization of a unique osteoinductive factor from bovine bone. J Biol Chem 1989; 264: 2805.
    PubMedGoogle Scholar
  • 14 Reddi AH, Wientroub MD, Muthukumaran N. Biologic principles of bone induction. Orthop Clin North Am 1987; 18 (2): 207.
    PubMedGoogle Scholar
  • 15 Urist MR, Kawamura M, Finerman GAM. Emerging knowledge of bone morphogenetic proteins and synergistic growth factors in the physiology of bone repair. Proc 36th Ann Meeting Orthop Res Soc 1990: 2.
    PubMedGoogle Scholar
  • 16 Mohan S, Bautista CM, Wergedal JE, Bay-link DJ. Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: A potential local regulator of IGF action. Proc Natl Acad Sci USA 1989; 86: 8338.
    CrossrefPubMedGoogle Scholar
  • 17 Linkhart A, Mohan S. Parathyroid hormone stimulates releases of insulin-like growth factor I (IGF-I) and IGF-II from neonatal mouse calvaria in organ culture. Endocrinology 1989; 125: 1484.
    CrossrefPubMedGoogle Scholar
  • 18 Gray TK, Mohan S, Linkhart TA, Baylink DJ. Estradiol stimulates in vitro secretion of insulin-like growth factors by the clonal osteoblastic cell line URM 106. Biochem Biophys Res Commun 1989; 158: 407.
    CrossrefPubMedGoogle Scholar
  • 19 Baxter RC, Martin JL. Binding proteins for the insulin-like growth factors: Structure, regulation and function. Prog Growth Factor Res 1989; 1: 49.
    CrossrefPubMedGoogle Scholar
  • 20 Schmid C, Ernst M, Zapf J, Foresch ER. Release of insulin-like growth factor carrier proteins by osteoblasts: Stimulation by estradiol and growth hormone. Biochem Biophys Res Commun 1989; 160: 788.
    CrossrefPubMedGoogle Scholar
  • 21 Howard GA, Drivdahl RH, Baylink DJ. Evidence for production and partial characterization of a coupling factor in bone metabolism. Calcif Tissue Int 1980; 31: 53.
    PubMedGoogle Scholar
  • 22 Mohan S, Jennings JC, Linkhart TA, Bay-link DJ. Primary structure of human skeletal growth factor: Homology with human insulin-like growth factor II. Biochem Biophys Acta 1988; 966: 44.
    CrossrefPubMedGoogle Scholar
  • 23 Wergedal JE, Mohan S, Lundy M, Baylink DJ. Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells. J Bone Min Res 1990; 5: 179.
    CrossrefPubMedGoogle Scholar
  • 24 Linkhart S, Mohan S, Linkhart TA. et al. Human skeletal growth factor stimulates collagen synthesis and inhibits proliferation of a clonal osteoblast cell line. J Cell Physiol 1985; 128: 307.
    PubMedGoogle Scholar
  • 25 Strong DD, Wergedal JE, Beachler AL. et al. Skeletal growth factor and transforming growth factor beta-1 enhance expression for type I collagen mRNA in human osteoblast-like cells. Endocrine Society 70th Ann Meeting 1988
    PubMedGoogle Scholar
  • 26 O’Connor-McCourt MD, Wakefield LM. Latent transforming growth factor beta in serum. J Biol Chem 1987; 261: 1490.
    PubMedGoogle Scholar
  • 27 Centrella M, McCarthy TL, Canalis E. Transforming growth factor beta is a Afunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. J Biol Chem 1987; 262: 2869.
    PubMedGoogle Scholar
  • 28 Pfeilschifter J, D’Souza SM, Mundy GR. Effects of transforming growth factor-beta on osteoblastic osteosarcoma cells. Endocrinology 1987; 121: 212.
    CrossrefPubMedGoogle Scholar
  • 29 Kasperk C, Wergedal JE, Mohan S. et al. Interactions of growth factors present in bone matrix and bone cells: Effects on DNA synthesis and alkaline phosphatase. Growth Factors 1990; 3: 147.
    CrossrefPubMedGoogle Scholar
  • 30 Datta HM, Zaidi M, Champaneri JB, Maclntyre I. Transforming growth factor-beta induced mitogenesis of human bone cancer cells. Biochem Biophys Res Commun 1989; 161: 672.
    CrossrefPubMedGoogle Scholar
  • 31 Jennings JC, Mohan S, Linkhart TA. et al. Comparison of the biological actions of TGF beta-1 and TGF beta-2: Differential activity in endothelial cells. J Cell Physiol 1989; 137: 167.
    PubMedGoogle Scholar
  • 32 Noda M, Rodan GA. Type beta transforming growth factor inhibits proliferation and expression of alkaline phosphatase activity in murine osteoblast-like cells. Biochem Biophys Res Commun 1986; 140: 56.
    CrossrefPubMedGoogle Scholar
  • 33 Skantze KA, Brinckerhoff CE, Collier JP. Use of agarose culture to measure the effect of transforming growth factor beta and epidermal growth factor on rabbit articular chondrocytes. Cancer Res 1985; 45: 4416.
    PubMedGoogle Scholar
  • 34 Seyedin SM, Thomas TC, Thompson DM. et al. Purification and characterization of two cartilage-inducing factors from bovine demineralized bone. Proc Natl Acad Sci USA 1985; 82: 2267.
    CrossrefPubMedGoogle Scholar
  • 35 Joyce ME, Jingushi S, Roberts AB. et al. Transforming growth factor-beta initiates cartilage and bone formation in vivo. J Bone Min Res 1989; 4: 259.
    PubMedGoogle Scholar
  • 36 MacDonald BR, Mundy GR, Clark S. Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long term bone marrow cultures. J Bone Min Res 1986; 1: 227.
    PubMedGoogle Scholar
  • 37 Tashjian AH, Voelker EE, Lazzaro M. et al. Alpha and beta transforming growth factors stimulate prostaglandin production and bone resorption in culture mouse calvaria. Proc Natl Acad Sci USA 1985; 82: 4543.
    PubMedGoogle Scholar
  • 38 Gospodarowicz D. Localization of a fibro-blast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 1974; 249: 123.
    CrossrefPubMedGoogle Scholar
  • 39 Globus RK, Plouet J, Gospodarowicz D. Cultured bovine cells synthesize basic fibroblast growth factor and transforming growth factor beta. Endocrinology 1989; 124: 1539.
    CrossrefPubMedGoogle Scholar
  • 40 Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G. Structural characterization and biological functions of fibroblast growth factor. Endocrinol Rev 1987; 8: 95.
    CrossrefPubMedGoogle Scholar
  • 41 Rodan SB, Wesolowski G, Thomas K, Rodan GA. Growth stimulation of rat calvaria osteoblastic cells by acidic fibroblast growth factor. Endocrinology 1987; 121: 1917.
    CrossrefPubMedGoogle Scholar
  • 42 Cuevas P, Burgos J, Baird A. Basic fibro-blast growth factor (FGF ) promotes cartilage repair in vivo. Biochem Biophys Res Commun 1988; 156: 611.
    CrossrefPubMedGoogle Scholar
  • 43 Bautista CM, Mohan Baylink DJ. Insulin-like growth factors I and II are present in the skeletal tissues of ten vertebrates. Metabolism 1990; 39: 96.
    PubMedGoogle Scholar
  • 44 McCarthy TL, Centrella M, Canalis E. Parathyroid hormone enchances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology 1989; 124: 1247.
    CrossrefPubMedGoogle Scholar
  • 45 Linkhart TA, Jennings JC, Mohan S. et al. Characterization of mitogenic activities extracted from bovine bone matrix. Bone 1986; 7: 479.
    CrossrefPubMedGoogle Scholar
  • 46 Tashjian AH, Hohman EL, Antoniades HN, Levine L. Platelet-derived growth factor stimulates bone resorption via a prostaglandin mediated mechanism. Endocrinology 1982; 111: 118.
    CrossrefPubMedGoogle Scholar